New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri

Six new cembranoids, cherbonolides A−E (1–5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical meth...

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Autores principales: Peng, Chia-Chi, Huang, Chiung-Yao, Ahmed, Atallah F., Hwang, Tsong-Long, Dai, Chang-Feng, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117711/
https://www.ncbi.nlm.nih.gov/pubmed/30082637
http://dx.doi.org/10.3390/md16080276
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author Peng, Chia-Chi
Huang, Chiung-Yao
Ahmed, Atallah F.
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
author_facet Peng, Chia-Chi
Huang, Chiung-Yao
Ahmed, Atallah F.
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
author_sort Peng, Chia-Chi
collection PubMed
description Six new cembranoids, cherbonolides A−E (1–5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 1–7 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils.
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spelling pubmed-61177112018-09-05 New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri Peng, Chia-Chi Huang, Chiung-Yao Ahmed, Atallah F. Hwang, Tsong-Long Dai, Chang-Feng Sheu, Jyh-Horng Mar Drugs Article Six new cembranoids, cherbonolides A−E (1–5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 1–7 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils. MDPI 2018-08-06 /pmc/articles/PMC6117711/ /pubmed/30082637 http://dx.doi.org/10.3390/md16080276 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peng, Chia-Chi
Huang, Chiung-Yao
Ahmed, Atallah F.
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_full New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_fullStr New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_full_unstemmed New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_short New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_sort new cembranoids and a biscembranoid peroxide from the soft coral sarcophyton cherbonnieri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117711/
https://www.ncbi.nlm.nih.gov/pubmed/30082637
http://dx.doi.org/10.3390/md16080276
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