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Evaluation of serum cathepsin D concentrations in coronary artery disease
BACKGROUND: Coronary artery disease (CAD) cannot be sufficiently explained by the presence of traditional risk factors. Cathepsin D has been proposed to serve as a surrogate marker of atherosclerosis but its alterations in CAD patients have not been studied. OBJECTIVE: To evaluate serum cathepsin D...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117802/ https://www.ncbi.nlm.nih.gov/pubmed/30170638 http://dx.doi.org/10.1016/j.ihj.2018.01.003 |
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author | Mohammadpour, Amir Hooshang Salehinejad, Zakieh Elyasi, Sepideh Mouhebati, Mohsen Mirhafez, Seyed Reza Samadi, Sara Ghayour-Mobarhan, Majid Ferns, Gordon Sahebkar, Amirhossein |
author_facet | Mohammadpour, Amir Hooshang Salehinejad, Zakieh Elyasi, Sepideh Mouhebati, Mohsen Mirhafez, Seyed Reza Samadi, Sara Ghayour-Mobarhan, Majid Ferns, Gordon Sahebkar, Amirhossein |
author_sort | Mohammadpour, Amir Hooshang |
collection | PubMed |
description | BACKGROUND: Coronary artery disease (CAD) cannot be sufficiently explained by the presence of traditional risk factors. Cathepsin D has been proposed to serve as a surrogate marker of atherosclerosis but its alterations in CAD patients have not been studied. OBJECTIVE: To evaluate serum cathepsin D concentrations in relation to the presence and severity of CAD. MATERIALS AND METHODS: A total of 104 subjects were recruited; 71 patients with suspected CAD and 33 healthy subjects. Thirty-four patients had >50% coronary stenosis of at least one artery (CAD+); the remaining 37 patients had <50% stenosis (CAD−) based on angiography. CAD+ patients were sub-divided into three sub-groups with single (SVD; n = 15), double (2VD; n = 9), and triple vessel (3VD; n = 10) disease. Serum soluble cathepsin D concentrations were determined using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum cathepsin D concentrations were significantly higher in the CAD+ compared with healthy control (p = 0.016) but not CAD− group (p = 0.098). Within the CAD+ group, patients with 3VD had significantly higher serum cathepsin D concentrations compared with the SVD group (p = 0.025), and also compared with the CAD− (p = 0.011) and SVD (p = 0.001) groups. No significant associations were found between serum cathepsin D concentrations and potential confounders including age, sex, blood pressure, smoking history and dyslipidemia. CONCLUSION: Serum cathepsin D concentrations may be associated with the presence of CAD. |
format | Online Article Text |
id | pubmed-6117802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-61178022019-07-01 Evaluation of serum cathepsin D concentrations in coronary artery disease Mohammadpour, Amir Hooshang Salehinejad, Zakieh Elyasi, Sepideh Mouhebati, Mohsen Mirhafez, Seyed Reza Samadi, Sara Ghayour-Mobarhan, Majid Ferns, Gordon Sahebkar, Amirhossein Indian Heart J Clinical and Preventive Cardiology BACKGROUND: Coronary artery disease (CAD) cannot be sufficiently explained by the presence of traditional risk factors. Cathepsin D has been proposed to serve as a surrogate marker of atherosclerosis but its alterations in CAD patients have not been studied. OBJECTIVE: To evaluate serum cathepsin D concentrations in relation to the presence and severity of CAD. MATERIALS AND METHODS: A total of 104 subjects were recruited; 71 patients with suspected CAD and 33 healthy subjects. Thirty-four patients had >50% coronary stenosis of at least one artery (CAD+); the remaining 37 patients had <50% stenosis (CAD−) based on angiography. CAD+ patients were sub-divided into three sub-groups with single (SVD; n = 15), double (2VD; n = 9), and triple vessel (3VD; n = 10) disease. Serum soluble cathepsin D concentrations were determined using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum cathepsin D concentrations were significantly higher in the CAD+ compared with healthy control (p = 0.016) but not CAD− group (p = 0.098). Within the CAD+ group, patients with 3VD had significantly higher serum cathepsin D concentrations compared with the SVD group (p = 0.025), and also compared with the CAD− (p = 0.011) and SVD (p = 0.001) groups. No significant associations were found between serum cathepsin D concentrations and potential confounders including age, sex, blood pressure, smoking history and dyslipidemia. CONCLUSION: Serum cathepsin D concentrations may be associated with the presence of CAD. Elsevier 2018 2018-01-08 /pmc/articles/PMC6117802/ /pubmed/30170638 http://dx.doi.org/10.1016/j.ihj.2018.01.003 Text en © 2018 Cardiological Society of India. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Clinical and Preventive Cardiology Mohammadpour, Amir Hooshang Salehinejad, Zakieh Elyasi, Sepideh Mouhebati, Mohsen Mirhafez, Seyed Reza Samadi, Sara Ghayour-Mobarhan, Majid Ferns, Gordon Sahebkar, Amirhossein Evaluation of serum cathepsin D concentrations in coronary artery disease |
title | Evaluation of serum cathepsin D concentrations in coronary artery disease |
title_full | Evaluation of serum cathepsin D concentrations in coronary artery disease |
title_fullStr | Evaluation of serum cathepsin D concentrations in coronary artery disease |
title_full_unstemmed | Evaluation of serum cathepsin D concentrations in coronary artery disease |
title_short | Evaluation of serum cathepsin D concentrations in coronary artery disease |
title_sort | evaluation of serum cathepsin d concentrations in coronary artery disease |
topic | Clinical and Preventive Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117802/ https://www.ncbi.nlm.nih.gov/pubmed/30170638 http://dx.doi.org/10.1016/j.ihj.2018.01.003 |
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