Cargando…

A case of undifferentiated pleomorphic sarcoma of the breast with lung and bone metastases

INTRODUCTION: Undifferentiated pleomorphic sarcoma (UPS) constitutes less than of all sarcomas in adults and rarely involves the breast. We herein present a patient with UPS of the breast with lung and bone metastases. This case was treated by eribulin as first chemotherapy, and performed mastectomy...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamazaki, Haruhiko, Shimizu, Satoru, Yoshida, Tatsuya, Suganuma, Nobuyasu, Yamanaka, Takashi, Yamashita, Toshinari, Rino, Yasushi, Masuda, Munetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117951/
https://www.ncbi.nlm.nih.gov/pubmed/30165321
http://dx.doi.org/10.1016/j.ijscr.2018.07.049
_version_ 1783351845924634624
author Yamazaki, Haruhiko
Shimizu, Satoru
Yoshida, Tatsuya
Suganuma, Nobuyasu
Yamanaka, Takashi
Yamashita, Toshinari
Rino, Yasushi
Masuda, Munetaka
author_facet Yamazaki, Haruhiko
Shimizu, Satoru
Yoshida, Tatsuya
Suganuma, Nobuyasu
Yamanaka, Takashi
Yamashita, Toshinari
Rino, Yasushi
Masuda, Munetaka
author_sort Yamazaki, Haruhiko
collection PubMed
description INTRODUCTION: Undifferentiated pleomorphic sarcoma (UPS) constitutes less than of all sarcomas in adults and rarely involves the breast. We herein present a patient with UPS of the breast with lung and bone metastases. This case was treated by eribulin as first chemotherapy, and performed mastectomy for local control. CASE PRESENTATION: A 55-year-old female presented a tumor measuring over 5 cm with pain in the right breast. Pathology of the incisional biopsy specimen led to a diagnosis of UPS. Computed tomography revealed a right tumor, right pubic tumor with osteolysis, and multiple lung metastases. She was started on eribulin; however, the tumor grew in size, indicating progressive disease, and the patient underwent simple mastectomy for local control. Pathological evaluation of the excised tumor was consistent with UPS. The patient elected palliative treatment and died due to respiratory failure caused by multiple lung metastases that exacerbated four months after surgery. DISCUSSION: Soft tissue sarcomas with distant metastases are treated with chemotherapy; however, there are currently no effective chemotherapeutic agents for UPS of the breast. Given the potential efficacy of eribulin in soft tissue tumors and the easy management of associated side effects, the patient was treated with eribulin, which however was insufficient for disease control. CONCLUSION: The prognosis of UPS with distant metastasis remains poor. Treatment approaches including chemotherapy and surgery should be considered based on the patient's general condition, prognosis, and expectations on quality of life.
format Online
Article
Text
id pubmed-6117951
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-61179512018-08-31 A case of undifferentiated pleomorphic sarcoma of the breast with lung and bone metastases Yamazaki, Haruhiko Shimizu, Satoru Yoshida, Tatsuya Suganuma, Nobuyasu Yamanaka, Takashi Yamashita, Toshinari Rino, Yasushi Masuda, Munetaka Int J Surg Case Rep Article INTRODUCTION: Undifferentiated pleomorphic sarcoma (UPS) constitutes less than of all sarcomas in adults and rarely involves the breast. We herein present a patient with UPS of the breast with lung and bone metastases. This case was treated by eribulin as first chemotherapy, and performed mastectomy for local control. CASE PRESENTATION: A 55-year-old female presented a tumor measuring over 5 cm with pain in the right breast. Pathology of the incisional biopsy specimen led to a diagnosis of UPS. Computed tomography revealed a right tumor, right pubic tumor with osteolysis, and multiple lung metastases. She was started on eribulin; however, the tumor grew in size, indicating progressive disease, and the patient underwent simple mastectomy for local control. Pathological evaluation of the excised tumor was consistent with UPS. The patient elected palliative treatment and died due to respiratory failure caused by multiple lung metastases that exacerbated four months after surgery. DISCUSSION: Soft tissue sarcomas with distant metastases are treated with chemotherapy; however, there are currently no effective chemotherapeutic agents for UPS of the breast. Given the potential efficacy of eribulin in soft tissue tumors and the easy management of associated side effects, the patient was treated with eribulin, which however was insufficient for disease control. CONCLUSION: The prognosis of UPS with distant metastasis remains poor. Treatment approaches including chemotherapy and surgery should be considered based on the patient's general condition, prognosis, and expectations on quality of life. Elsevier 2018-08-16 /pmc/articles/PMC6117951/ /pubmed/30165321 http://dx.doi.org/10.1016/j.ijscr.2018.07.049 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Yamazaki, Haruhiko
Shimizu, Satoru
Yoshida, Tatsuya
Suganuma, Nobuyasu
Yamanaka, Takashi
Yamashita, Toshinari
Rino, Yasushi
Masuda, Munetaka
A case of undifferentiated pleomorphic sarcoma of the breast with lung and bone metastases
title A case of undifferentiated pleomorphic sarcoma of the breast with lung and bone metastases
title_full A case of undifferentiated pleomorphic sarcoma of the breast with lung and bone metastases
title_fullStr A case of undifferentiated pleomorphic sarcoma of the breast with lung and bone metastases
title_full_unstemmed A case of undifferentiated pleomorphic sarcoma of the breast with lung and bone metastases
title_short A case of undifferentiated pleomorphic sarcoma of the breast with lung and bone metastases
title_sort case of undifferentiated pleomorphic sarcoma of the breast with lung and bone metastases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117951/
https://www.ncbi.nlm.nih.gov/pubmed/30165321
http://dx.doi.org/10.1016/j.ijscr.2018.07.049
work_keys_str_mv AT yamazakiharuhiko acaseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT shimizusatoru acaseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT yoshidatatsuya acaseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT suganumanobuyasu acaseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT yamanakatakashi acaseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT yamashitatoshinari acaseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT rinoyasushi acaseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT masudamunetaka acaseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT yamazakiharuhiko caseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT shimizusatoru caseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT yoshidatatsuya caseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT suganumanobuyasu caseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT yamanakatakashi caseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT yamashitatoshinari caseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT rinoyasushi caseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases
AT masudamunetaka caseofundifferentiatedpleomorphicsarcomaofthebreastwithlungandbonemetastases