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Dexmedetomidine attenuates the propofol-induced long-term neurotoxicity in the developing brain of rats by enhancing the PI3K/Akt signaling pathway

BACKGROUND: Propofol induces short- and long-term neurotoxicity. Our previous study showed that dexmedetomidine (Dex) can attenuate the propofol-induced acute neurotoxicity in rodents by enhancing the PI3K/Akt signaling. However, whether treatment of young rats with Dex could protect them from long-...

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Detalles Bibliográficos
Autores principales:	Xiao, Yong, Zhou, Lifang, Tu, Youbing, Li, Yuantao, Liang, Yubing, Zhang, Xu, Lv, Jing, Zhong, Yu, Xie, Yubo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118247/ https://www.ncbi.nlm.nih.gov/pubmed/30214209 http://dx.doi.org/10.2147/NDT.S169099

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