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Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety

BACKGROUND: Postoperative endophthalmitis is a severe complication after intraocular surgery. The aim of this pilot study was to investigate the safety of intracameral cefuroxime in combined vitrectomy and phacoemulsification for cataract and various vitreoretinal disease. METHODS: The charts of 152...

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Autores principales: Besozzi, Gianluca, Di Salvatore, Attilio, Cardillo, Daniele, Finzi, Alessandro, Pinackatt, Joseph Sajish, Baldi, Andrea, Monfardini, Alessandro, Forioli, Valeria, Frisina, Rino, Parolini, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118255/
https://www.ncbi.nlm.nih.gov/pubmed/30214140
http://dx.doi.org/10.2147/OPTH.S170751
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author Besozzi, Gianluca
Di Salvatore, Attilio
Cardillo, Daniele
Finzi, Alessandro
Pinackatt, Joseph Sajish
Baldi, Andrea
Monfardini, Alessandro
Forioli, Valeria
Frisina, Rino
Parolini, Barbara
author_facet Besozzi, Gianluca
Di Salvatore, Attilio
Cardillo, Daniele
Finzi, Alessandro
Pinackatt, Joseph Sajish
Baldi, Andrea
Monfardini, Alessandro
Forioli, Valeria
Frisina, Rino
Parolini, Barbara
author_sort Besozzi, Gianluca
collection PubMed
description BACKGROUND: Postoperative endophthalmitis is a severe complication after intraocular surgery. The aim of this pilot study was to investigate the safety of intracameral cefuroxime in combined vitrectomy and phacoemulsification for cataract and various vitreoretinal disease. METHODS: The charts of 152 patients who underwent combined phacoemulsification, intraocular lens implant and pars plana vitrectomy were reviewed. The final tamponade was chosen among fluid, air, gas or silicone oil, based on the requirement of each single case. Patients were operated on by four different surgeons. At the end of surgery, 1 mg/0.1 mL of intracameral cefuroxime (Aprokam) was administered. RESULTS: The mean follow-up was 6.26±7.78 months (range 1–12). No retinal complication, such as retinal infarction or hemorrhages were observed. No acute macular serous detachment and no new intraretinal cysts were noted, in those patients who received optical coherence tomography within the fifth day after surgery. No endophthalmitis was recorded. CONCLUSION: Intracameral cefuroxime, at the end of combined phacoemulsification and pars plana vitrectomy, is safe as it has no toxicity on the retina and maybe could be considered effective in endophthalmitis prevention. Due to the relatively small number of patients, further studies are advisable. SUMMARY STATEMENT: The standard dose of intracameral cefuroxime at the end of combined phacoemulsification and pars plana vitrectomy has no toxic effects on the retina. This paper/The abstract of this paper was presented at the European Vitreo Retinal Society Conference 2017 as a conference talk with interim findings. The poster’s abstract was not published.
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spelling pubmed-61182552018-09-13 Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety Besozzi, Gianluca Di Salvatore, Attilio Cardillo, Daniele Finzi, Alessandro Pinackatt, Joseph Sajish Baldi, Andrea Monfardini, Alessandro Forioli, Valeria Frisina, Rino Parolini, Barbara Clin Ophthalmol Original Research BACKGROUND: Postoperative endophthalmitis is a severe complication after intraocular surgery. The aim of this pilot study was to investigate the safety of intracameral cefuroxime in combined vitrectomy and phacoemulsification for cataract and various vitreoretinal disease. METHODS: The charts of 152 patients who underwent combined phacoemulsification, intraocular lens implant and pars plana vitrectomy were reviewed. The final tamponade was chosen among fluid, air, gas or silicone oil, based on the requirement of each single case. Patients were operated on by four different surgeons. At the end of surgery, 1 mg/0.1 mL of intracameral cefuroxime (Aprokam) was administered. RESULTS: The mean follow-up was 6.26±7.78 months (range 1–12). No retinal complication, such as retinal infarction or hemorrhages were observed. No acute macular serous detachment and no new intraretinal cysts were noted, in those patients who received optical coherence tomography within the fifth day after surgery. No endophthalmitis was recorded. CONCLUSION: Intracameral cefuroxime, at the end of combined phacoemulsification and pars plana vitrectomy, is safe as it has no toxicity on the retina and maybe could be considered effective in endophthalmitis prevention. Due to the relatively small number of patients, further studies are advisable. SUMMARY STATEMENT: The standard dose of intracameral cefuroxime at the end of combined phacoemulsification and pars plana vitrectomy has no toxic effects on the retina. This paper/The abstract of this paper was presented at the European Vitreo Retinal Society Conference 2017 as a conference talk with interim findings. The poster’s abstract was not published. Dove Medical Press 2018-08-28 /pmc/articles/PMC6118255/ /pubmed/30214140 http://dx.doi.org/10.2147/OPTH.S170751 Text en © 2018 Besozzi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Besozzi, Gianluca
Di Salvatore, Attilio
Cardillo, Daniele
Finzi, Alessandro
Pinackatt, Joseph Sajish
Baldi, Andrea
Monfardini, Alessandro
Forioli, Valeria
Frisina, Rino
Parolini, Barbara
Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_full Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_fullStr Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_full_unstemmed Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_short Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_sort intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118255/
https://www.ncbi.nlm.nih.gov/pubmed/30214140
http://dx.doi.org/10.2147/OPTH.S170751
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