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Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate

Carboxylesterase 1 (CES1) metabolizes methylphenidate and other drugs. CES1 gene variation only partially explains pharmacokinetic (PK) variability. Biomarkers predicting the PKs of drugs metabolized by CES1 are needed. We identified lipids in plasma from 44 healthy subjects that correlated with CES...

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Detalles Bibliográficos
Autores principales:	Kaddurah‐Daouk, Rima, Hankemeier, Thomas, Scholl, Elizabeth H., Baillie, Rebecca, Harms, Amy, Stage, Claus, Dalhoff, Kim P., Jűrgens, Gesche, Taboureau, Olivier, Nzabonimpa, Grace S., Motsinger‐Reif, Alison A., Thomsen, Ragnar, Linnet, Kristian, Rasmussen, Henrik B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118295/ https://www.ncbi.nlm.nih.gov/pubmed/30169917 http://dx.doi.org/10.1002/psp4.12309

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