Multifocal thymic cysts with cholesterol granuloma

A 56‐year‐old female presented to our department with chest discomfort. Contrast‐enhanced computed tomography (CT) revealed a cyst and nodule in the anterior mediastinum; positron emission tomography–CT showed an increased uptake in the nodule. Total thymectomy was performed to obtain a definitive diagnosis and treatment. A pathological diagnosis of multifocal thymic cysts with cholesterol granuloma was made. Microscopic examination revealed different‐sized cysts scattered in the thymus. These cysts were filled with cholesterol clefts and manifested three different phase characters. The nodule comprised granuloma‐containing cholesterol clefts. We report a rare case of a patient whose histopathology presented a series of cholesterol granuloma formations.