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Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach
Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118819/ https://www.ncbi.nlm.nih.gov/pubmed/30082021 http://dx.doi.org/10.7554/eLife.36709 |
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author | Kostaki, Evangelia-Georgia Karamitros, Timokratis Stefanou, Garyfallia Mamais, Ioannis Angelis, Konstantinos Hatzakis, Angelos Kramvis, Anna Paraskevis, Dimitrios |
author_facet | Kostaki, Evangelia-Georgia Karamitros, Timokratis Stefanou, Garyfallia Mamais, Ioannis Angelis, Konstantinos Hatzakis, Angelos Kramvis, Anna Paraskevis, Dimitrios |
author_sort | Kostaki, Evangelia-Georgia |
collection | PubMed |
description | Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct their global phylogeny. Phylogeographic analysis was conducted by the reconstruction of ancestral states using the criterion of parsimony. The putative origin of genotype D was in North Africa/Middle East. HBV-D sequences form low levels of regional clustering for the Middle East and Southern Europe. In contrast, HBV-A sequences form two major clusters, the first including sequences mostly from sub-Saharan Africa, and the second including sequences mostly from Western and Central Europe. Conclusion: We observed considerable differences in the global dissemination patterns of HBV-D and HBV-A and different levels of monophyletic clustering in relation to the regions of prevalence of each genotype. |
format | Online Article Text |
id | pubmed-6118819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61188192018-09-05 Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach Kostaki, Evangelia-Georgia Karamitros, Timokratis Stefanou, Garyfallia Mamais, Ioannis Angelis, Konstantinos Hatzakis, Angelos Kramvis, Anna Paraskevis, Dimitrios eLife Microbiology and Infectious Disease Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct their global phylogeny. Phylogeographic analysis was conducted by the reconstruction of ancestral states using the criterion of parsimony. The putative origin of genotype D was in North Africa/Middle East. HBV-D sequences form low levels of regional clustering for the Middle East and Southern Europe. In contrast, HBV-A sequences form two major clusters, the first including sequences mostly from sub-Saharan Africa, and the second including sequences mostly from Western and Central Europe. Conclusion: We observed considerable differences in the global dissemination patterns of HBV-D and HBV-A and different levels of monophyletic clustering in relation to the regions of prevalence of each genotype. eLife Sciences Publications, Ltd 2018-08-07 /pmc/articles/PMC6118819/ /pubmed/30082021 http://dx.doi.org/10.7554/eLife.36709 Text en © 2018, Kostaki et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Microbiology and Infectious Disease Kostaki, Evangelia-Georgia Karamitros, Timokratis Stefanou, Garyfallia Mamais, Ioannis Angelis, Konstantinos Hatzakis, Angelos Kramvis, Anna Paraskevis, Dimitrios Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach |
title | Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach |
title_full | Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach |
title_fullStr | Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach |
title_full_unstemmed | Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach |
title_short | Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach |
title_sort | unravelling the history of hepatitis b virus genotypes a and d infection using a full-genome phylogenetic and phylogeographic approach |
topic | Microbiology and Infectious Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118819/ https://www.ncbi.nlm.nih.gov/pubmed/30082021 http://dx.doi.org/10.7554/eLife.36709 |
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