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Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach

Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct...

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Autores principales: Kostaki, Evangelia-Georgia, Karamitros, Timokratis, Stefanou, Garyfallia, Mamais, Ioannis, Angelis, Konstantinos, Hatzakis, Angelos, Kramvis, Anna, Paraskevis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118819/
https://www.ncbi.nlm.nih.gov/pubmed/30082021
http://dx.doi.org/10.7554/eLife.36709
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author Kostaki, Evangelia-Georgia
Karamitros, Timokratis
Stefanou, Garyfallia
Mamais, Ioannis
Angelis, Konstantinos
Hatzakis, Angelos
Kramvis, Anna
Paraskevis, Dimitrios
author_facet Kostaki, Evangelia-Georgia
Karamitros, Timokratis
Stefanou, Garyfallia
Mamais, Ioannis
Angelis, Konstantinos
Hatzakis, Angelos
Kramvis, Anna
Paraskevis, Dimitrios
author_sort Kostaki, Evangelia-Georgia
collection PubMed
description Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct their global phylogeny. Phylogeographic analysis was conducted by the reconstruction of ancestral states using the criterion of parsimony. The putative origin of genotype D was in North Africa/Middle East. HBV-D sequences form low levels of regional clustering for the Middle East and Southern Europe. In contrast, HBV-A sequences form two major clusters, the first including sequences mostly from sub-Saharan Africa, and the second including sequences mostly from Western and Central Europe. Conclusion: We observed considerable differences in the global dissemination patterns of HBV-D and HBV-A and different levels of monophyletic clustering in relation to the regions of prevalence of each genotype.
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spelling pubmed-61188192018-09-05 Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach Kostaki, Evangelia-Georgia Karamitros, Timokratis Stefanou, Garyfallia Mamais, Ioannis Angelis, Konstantinos Hatzakis, Angelos Kramvis, Anna Paraskevis, Dimitrios eLife Microbiology and Infectious Disease Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct their global phylogeny. Phylogeographic analysis was conducted by the reconstruction of ancestral states using the criterion of parsimony. The putative origin of genotype D was in North Africa/Middle East. HBV-D sequences form low levels of regional clustering for the Middle East and Southern Europe. In contrast, HBV-A sequences form two major clusters, the first including sequences mostly from sub-Saharan Africa, and the second including sequences mostly from Western and Central Europe. Conclusion: We observed considerable differences in the global dissemination patterns of HBV-D and HBV-A and different levels of monophyletic clustering in relation to the regions of prevalence of each genotype. eLife Sciences Publications, Ltd 2018-08-07 /pmc/articles/PMC6118819/ /pubmed/30082021 http://dx.doi.org/10.7554/eLife.36709 Text en © 2018, Kostaki et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Microbiology and Infectious Disease
Kostaki, Evangelia-Georgia
Karamitros, Timokratis
Stefanou, Garyfallia
Mamais, Ioannis
Angelis, Konstantinos
Hatzakis, Angelos
Kramvis, Anna
Paraskevis, Dimitrios
Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach
title Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach
title_full Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach
title_fullStr Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach
title_full_unstemmed Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach
title_short Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach
title_sort unravelling the history of hepatitis b virus genotypes a and d infection using a full-genome phylogenetic and phylogeographic approach
topic Microbiology and Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118819/
https://www.ncbi.nlm.nih.gov/pubmed/30082021
http://dx.doi.org/10.7554/eLife.36709
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