E-cadherin in Contact Inhibition and Cancer

E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expressi...

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Detalles Bibliográficos
Autores principales: Mendonsa, Alisha, Na, Tae-Young, Gumbiner, Barry M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119098/
https://www.ncbi.nlm.nih.gov/pubmed/29780167
http://dx.doi.org/10.1038/s41388-018-0304-2
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author Mendonsa, Alisha
Na, Tae-Young
Gumbiner, Barry M
author_facet Mendonsa, Alisha
Na, Tae-Young
Gumbiner, Barry M
author_sort Mendonsa, Alisha
collection PubMed
description E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer.
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spelling pubmed-61190982018-11-21 E-cadherin in Contact Inhibition and Cancer Mendonsa, Alisha Na, Tae-Young Gumbiner, Barry M Oncogene Article E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer. 2018-05-21 2018-08 /pmc/articles/PMC6119098/ /pubmed/29780167 http://dx.doi.org/10.1038/s41388-018-0304-2 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Mendonsa, Alisha
Na, Tae-Young
Gumbiner, Barry M
E-cadherin in Contact Inhibition and Cancer
title E-cadherin in Contact Inhibition and Cancer
title_full E-cadherin in Contact Inhibition and Cancer
title_fullStr E-cadherin in Contact Inhibition and Cancer
title_full_unstemmed E-cadherin in Contact Inhibition and Cancer
title_short E-cadherin in Contact Inhibition and Cancer
title_sort e-cadherin in contact inhibition and cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119098/
https://www.ncbi.nlm.nih.gov/pubmed/29780167
http://dx.doi.org/10.1038/s41388-018-0304-2
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AT gumbinerbarrym ecadherinincontactinhibitionandcancer

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