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Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway

BACKGROUND: Ischaemia reperfusion (IR) induces multiple pathophysiological changes. In addition to its classical role in regulating tumourigenesis, the feedback loop formed by p53 and its driven target p53-upregulated modulator of apoptosis (PUMA) was recently demonstrated to be the common node tigh...

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Detalles Bibliográficos
Autores principales:	Li, Xiao-Qian, Yu, Qian, Chen, Feng-Shou, Tan, Wen-Fei, Zhang, Zai-Li, Ma, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119253/ https://www.ncbi.nlm.nih.gov/pubmed/30172256 http://dx.doi.org/10.1186/s12974-018-1271-9

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