Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service

BACKGROUND: In adult studies the MTHFR C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children. METHODS: A retrospective study of children referred with headache to a tertiary level Paediatric Neurology Service between 200...

Descripción completa

Detalles Bibliográficos
Autores principales: Orsini, A., Sammartino, I., Valetto, A., Bertini, V., Marchese, P., Bonuccelli, A., Peroni, D. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119283/
https://www.ncbi.nlm.nih.gov/pubmed/30170616
http://dx.doi.org/10.1186/s13052-018-0546-1
_version_ 1783352058779271168
author Orsini, A.
Sammartino, I.
Valetto, A.
Bertini, V.
Marchese, P.
Bonuccelli, A.
Peroni, D. G.
author_facet Orsini, A.
Sammartino, I.
Valetto, A.
Bertini, V.
Marchese, P.
Bonuccelli, A.
Peroni, D. G.
author_sort Orsini, A.
collection PubMed
description BACKGROUND: In adult studies the MTHFR C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children. METHODS: A retrospective study of children referred with headache to a tertiary level Paediatric Neurology Service between 2008 and 2012. This study included only patients who had been genotyped for the MTHFR C677T polymorphism. An evaluation of homocysteine serum levels was necessary to exclude other types of migraine. CONCLUSION: Compared with the wild-type genotype, the T/T genotype was associated with an increased risk of any type of migraine, though the statistical significance was greatest in migraine with aura. The homocysteine serum levels were significantly higher in migraine with aura compared to migraine without aura. In a pediatric population MTHFR T/T homozygosity influences susceptibility to migraine.
format Online
Article
Text
id pubmed-6119283
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-61192832018-09-05 Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service Orsini, A. Sammartino, I. Valetto, A. Bertini, V. Marchese, P. Bonuccelli, A. Peroni, D. G. Ital J Pediatr Research BACKGROUND: In adult studies the MTHFR C677T polymorphism has been associated with an increased risk of migraine, but little research has been done in this area in children. METHODS: A retrospective study of children referred with headache to a tertiary level Paediatric Neurology Service between 2008 and 2012. This study included only patients who had been genotyped for the MTHFR C677T polymorphism. An evaluation of homocysteine serum levels was necessary to exclude other types of migraine. CONCLUSION: Compared with the wild-type genotype, the T/T genotype was associated with an increased risk of any type of migraine, though the statistical significance was greatest in migraine with aura. The homocysteine serum levels were significantly higher in migraine with aura compared to migraine without aura. In a pediatric population MTHFR T/T homozygosity influences susceptibility to migraine. BioMed Central 2018-08-31 /pmc/articles/PMC6119283/ /pubmed/30170616 http://dx.doi.org/10.1186/s13052-018-0546-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Orsini, A.
Sammartino, I.
Valetto, A.
Bertini, V.
Marchese, P.
Bonuccelli, A.
Peroni, D. G.
Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service
title Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service
title_full Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service
title_fullStr Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service
title_full_unstemmed Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service
title_short Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service
title_sort methylenetetrahydrofolate reductase polymorphism (mthfr c677t) and headache in children: a retrospective study from a tertiary level outpatient service
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119283/
https://www.ncbi.nlm.nih.gov/pubmed/30170616
http://dx.doi.org/10.1186/s13052-018-0546-1
work_keys_str_mv AT orsinia methylenetetrahydrofolatereductasepolymorphismmthfrc677tandheadacheinchildrenaretrospectivestudyfromatertiaryleveloutpatientservice
AT sammartinoi methylenetetrahydrofolatereductasepolymorphismmthfrc677tandheadacheinchildrenaretrospectivestudyfromatertiaryleveloutpatientservice
AT valettoa methylenetetrahydrofolatereductasepolymorphismmthfrc677tandheadacheinchildrenaretrospectivestudyfromatertiaryleveloutpatientservice
AT bertiniv methylenetetrahydrofolatereductasepolymorphismmthfrc677tandheadacheinchildrenaretrospectivestudyfromatertiaryleveloutpatientservice
AT marchesep methylenetetrahydrofolatereductasepolymorphismmthfrc677tandheadacheinchildrenaretrospectivestudyfromatertiaryleveloutpatientservice
AT bonuccellia methylenetetrahydrofolatereductasepolymorphismmthfrc677tandheadacheinchildrenaretrospectivestudyfromatertiaryleveloutpatientservice
AT peronidg methylenetetrahydrofolatereductasepolymorphismmthfrc677tandheadacheinchildrenaretrospectivestudyfromatertiaryleveloutpatientservice

Ejemplares similares