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Effects of methylphenidate on cognition and behaviour in children with neurofibromatosis type 1: a study protocol for a randomised placebo-controlled crossover trial

INTRODUCTION: Dopamine dysregulation has been identified as a key modulator of behavioural impairment in neurofibromatosis type 1 (NF1) and a potential therapeutic target. Preclinical research demonstrates reduced dopamine in the brains of genetically engineered NF1 mouse strains is associated with...

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Detalles Bibliográficos
Autores principales:	Pride, Natalie A, Barton, Belinda, Hutchins, Paul, Coghill, David R, Korgaonkar, Mayuresh S, Hearps, Stephen J C, Rouel, Melissa, Malarbi, Stephanie, North, Kathryn N, Payne, Jonathan M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Pharmacology and Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119452/ https://www.ncbi.nlm.nih.gov/pubmed/30166301 http://dx.doi.org/10.1136/bmjopen-2018-021800

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