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Hyperpolarized (13)C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood–Brain Barrier in the Cerebral Uptake and Metabolism of l-Lactate in Vivo

[Image: see text] The dynamics of l-lactate transport across the blood–brain barrier (BBB) and its cerebral metabolism are still subject to debate. We studied lactate uptake and intracellular metabolism in the mouse brain using hyperpolarized (13)C magnetic resonance spectroscopy (MRS). Following th...

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Detalles Bibliográficos
Autores principales:	Takado, Yuhei, Cheng, Tian, Bastiaansen, Jessica A. M., Yoshihara, Hikari A. I., Lanz, Bernard, Mishkovsky, Mor, Lengacher, Sylvain, Comment, Arnaud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119468/ https://www.ncbi.nlm.nih.gov/pubmed/29771492 http://dx.doi.org/10.1021/acschemneuro.8b00066

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