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Risk Factors Associated with Survival of Pulmonary Tuberculosis
BACKGROUND: We conducted this study among adults with pulmonary tuberculosis (TB) who received treatment, in order to determine the risk factors associated with survival of during treatments. METHODS: A retrospective cohort study was conducted from 2005–2015 with newly registered TB patients in the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119565/ https://www.ncbi.nlm.nih.gov/pubmed/30181996 |
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author | KAZEMPOUR DIZAJI, Mehdi KAZEMNEJAD, Anoshirvan TABARSI, Payam ZAYERI, Farid |
author_facet | KAZEMPOUR DIZAJI, Mehdi KAZEMNEJAD, Anoshirvan TABARSI, Payam ZAYERI, Farid |
author_sort | KAZEMPOUR DIZAJI, Mehdi |
collection | PubMed |
description | BACKGROUND: We conducted this study among adults with pulmonary tuberculosis (TB) who received treatment, in order to determine the risk factors associated with survival of during treatments. METHODS: A retrospective cohort study was conducted from 2005–2015 with newly registered TB patients in the Hospital of Masih Daneshvari Doctor, Tehran, Iran. Overall, 5313 patients met our study’s cohort definition, but the analysis was performed on 2299 patients (43.2%) who had a correct address and they could be traced-out by the Medical – registry. Time in days was used in survival model and patients who were still alive (until last follow-up date) considered as censored. To study the effect of risk factors on patients’ survival, the generalized gamma regression model was used. RESULTS: Based on the results of univariate analysis, gender (RR=2 (95% CI: 1.1–3.7), high school education (Relative Risk: RR=0.3 (95% CI: 0.2–0.7), higher education (RR=0.3 (95% CI: 0.1–0.9), smoker (RR=2.5 (95% CI: 1.4–4.2), drug user (RR=2.4 (95% CI: 1.4–4), TB contact (RR=0.5 (95% CI: 0.3–0.8) and HIV positive (RR=4 (95% CI: 1.7–9.2) affected patients’ survival. Moreover, the results of multivariate analysis showed that, gender (RR=5.5 (95% CI: 2.2–13.5), age (RR=1.1 (95% CI: 1–1.1), adverse drug effect (RR=2.5 (95% CI: 1.2–5.4), smoker (RR=3.3 (95% CI: 1.2–9.4), TB contact (RR=0.2 (95% CI: 0.1–0.5), diabetic mellitus (RR=3 (95% CI: 1–8.3), HIV positive (RR=26 (95% CI: 4.6–145.9) and comorbidities (RR=4.9 (95% CI: 2–11.6) were identified as factors affecting patients’ survival. CONCLUSION: Our data indicated associated risk factors in TB mortality and could suggest way to progressing national tuberculosis program (NTP) for predicating and plan for effective interventional strategies. |
format | Online Article Text |
id | pubmed-6119565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-61195652018-09-04 Risk Factors Associated with Survival of Pulmonary Tuberculosis KAZEMPOUR DIZAJI, Mehdi KAZEMNEJAD, Anoshirvan TABARSI, Payam ZAYERI, Farid Iran J Public Health Original Article BACKGROUND: We conducted this study among adults with pulmonary tuberculosis (TB) who received treatment, in order to determine the risk factors associated with survival of during treatments. METHODS: A retrospective cohort study was conducted from 2005–2015 with newly registered TB patients in the Hospital of Masih Daneshvari Doctor, Tehran, Iran. Overall, 5313 patients met our study’s cohort definition, but the analysis was performed on 2299 patients (43.2%) who had a correct address and they could be traced-out by the Medical – registry. Time in days was used in survival model and patients who were still alive (until last follow-up date) considered as censored. To study the effect of risk factors on patients’ survival, the generalized gamma regression model was used. RESULTS: Based on the results of univariate analysis, gender (RR=2 (95% CI: 1.1–3.7), high school education (Relative Risk: RR=0.3 (95% CI: 0.2–0.7), higher education (RR=0.3 (95% CI: 0.1–0.9), smoker (RR=2.5 (95% CI: 1.4–4.2), drug user (RR=2.4 (95% CI: 1.4–4), TB contact (RR=0.5 (95% CI: 0.3–0.8) and HIV positive (RR=4 (95% CI: 1.7–9.2) affected patients’ survival. Moreover, the results of multivariate analysis showed that, gender (RR=5.5 (95% CI: 2.2–13.5), age (RR=1.1 (95% CI: 1–1.1), adverse drug effect (RR=2.5 (95% CI: 1.2–5.4), smoker (RR=3.3 (95% CI: 1.2–9.4), TB contact (RR=0.2 (95% CI: 0.1–0.5), diabetic mellitus (RR=3 (95% CI: 1–8.3), HIV positive (RR=26 (95% CI: 4.6–145.9) and comorbidities (RR=4.9 (95% CI: 2–11.6) were identified as factors affecting patients’ survival. CONCLUSION: Our data indicated associated risk factors in TB mortality and could suggest way to progressing national tuberculosis program (NTP) for predicating and plan for effective interventional strategies. Tehran University of Medical Sciences 2018-07 /pmc/articles/PMC6119565/ /pubmed/30181996 Text en Copyright© Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article KAZEMPOUR DIZAJI, Mehdi KAZEMNEJAD, Anoshirvan TABARSI, Payam ZAYERI, Farid Risk Factors Associated with Survival of Pulmonary Tuberculosis |
title | Risk Factors Associated with Survival of Pulmonary Tuberculosis |
title_full | Risk Factors Associated with Survival of Pulmonary Tuberculosis |
title_fullStr | Risk Factors Associated with Survival of Pulmonary Tuberculosis |
title_full_unstemmed | Risk Factors Associated with Survival of Pulmonary Tuberculosis |
title_short | Risk Factors Associated with Survival of Pulmonary Tuberculosis |
title_sort | risk factors associated with survival of pulmonary tuberculosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119565/ https://www.ncbi.nlm.nih.gov/pubmed/30181996 |
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