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Risk Factors Associated with Survival of Pulmonary Tuberculosis

BACKGROUND: We conducted this study among adults with pulmonary tuberculosis (TB) who received treatment, in order to determine the risk factors associated with survival of during treatments. METHODS: A retrospective cohort study was conducted from 2005–2015 with newly registered TB patients in the...

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Autores principales: KAZEMPOUR DIZAJI, Mehdi, KAZEMNEJAD, Anoshirvan, TABARSI, Payam, ZAYERI, Farid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119565/
https://www.ncbi.nlm.nih.gov/pubmed/30181996
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author KAZEMPOUR DIZAJI, Mehdi
KAZEMNEJAD, Anoshirvan
TABARSI, Payam
ZAYERI, Farid
author_facet KAZEMPOUR DIZAJI, Mehdi
KAZEMNEJAD, Anoshirvan
TABARSI, Payam
ZAYERI, Farid
author_sort KAZEMPOUR DIZAJI, Mehdi
collection PubMed
description BACKGROUND: We conducted this study among adults with pulmonary tuberculosis (TB) who received treatment, in order to determine the risk factors associated with survival of during treatments. METHODS: A retrospective cohort study was conducted from 2005–2015 with newly registered TB patients in the Hospital of Masih Daneshvari Doctor, Tehran, Iran. Overall, 5313 patients met our study’s cohort definition, but the analysis was performed on 2299 patients (43.2%) who had a correct address and they could be traced-out by the Medical – registry. Time in days was used in survival model and patients who were still alive (until last follow-up date) considered as censored. To study the effect of risk factors on patients’ survival, the generalized gamma regression model was used. RESULTS: Based on the results of univariate analysis, gender (RR=2 (95% CI: 1.1–3.7), high school education (Relative Risk: RR=0.3 (95% CI: 0.2–0.7), higher education (RR=0.3 (95% CI: 0.1–0.9), smoker (RR=2.5 (95% CI: 1.4–4.2), drug user (RR=2.4 (95% CI: 1.4–4), TB contact (RR=0.5 (95% CI: 0.3–0.8) and HIV positive (RR=4 (95% CI: 1.7–9.2) affected patients’ survival. Moreover, the results of multivariate analysis showed that, gender (RR=5.5 (95% CI: 2.2–13.5), age (RR=1.1 (95% CI: 1–1.1), adverse drug effect (RR=2.5 (95% CI: 1.2–5.4), smoker (RR=3.3 (95% CI: 1.2–9.4), TB contact (RR=0.2 (95% CI: 0.1–0.5), diabetic mellitus (RR=3 (95% CI: 1–8.3), HIV positive (RR=26 (95% CI: 4.6–145.9) and comorbidities (RR=4.9 (95% CI: 2–11.6) were identified as factors affecting patients’ survival. CONCLUSION: Our data indicated associated risk factors in TB mortality and could suggest way to progressing national tuberculosis program (NTP) for predicating and plan for effective interventional strategies.
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spelling pubmed-61195652018-09-04 Risk Factors Associated with Survival of Pulmonary Tuberculosis KAZEMPOUR DIZAJI, Mehdi KAZEMNEJAD, Anoshirvan TABARSI, Payam ZAYERI, Farid Iran J Public Health Original Article BACKGROUND: We conducted this study among adults with pulmonary tuberculosis (TB) who received treatment, in order to determine the risk factors associated with survival of during treatments. METHODS: A retrospective cohort study was conducted from 2005–2015 with newly registered TB patients in the Hospital of Masih Daneshvari Doctor, Tehran, Iran. Overall, 5313 patients met our study’s cohort definition, but the analysis was performed on 2299 patients (43.2%) who had a correct address and they could be traced-out by the Medical – registry. Time in days was used in survival model and patients who were still alive (until last follow-up date) considered as censored. To study the effect of risk factors on patients’ survival, the generalized gamma regression model was used. RESULTS: Based on the results of univariate analysis, gender (RR=2 (95% CI: 1.1–3.7), high school education (Relative Risk: RR=0.3 (95% CI: 0.2–0.7), higher education (RR=0.3 (95% CI: 0.1–0.9), smoker (RR=2.5 (95% CI: 1.4–4.2), drug user (RR=2.4 (95% CI: 1.4–4), TB contact (RR=0.5 (95% CI: 0.3–0.8) and HIV positive (RR=4 (95% CI: 1.7–9.2) affected patients’ survival. Moreover, the results of multivariate analysis showed that, gender (RR=5.5 (95% CI: 2.2–13.5), age (RR=1.1 (95% CI: 1–1.1), adverse drug effect (RR=2.5 (95% CI: 1.2–5.4), smoker (RR=3.3 (95% CI: 1.2–9.4), TB contact (RR=0.2 (95% CI: 0.1–0.5), diabetic mellitus (RR=3 (95% CI: 1–8.3), HIV positive (RR=26 (95% CI: 4.6–145.9) and comorbidities (RR=4.9 (95% CI: 2–11.6) were identified as factors affecting patients’ survival. CONCLUSION: Our data indicated associated risk factors in TB mortality and could suggest way to progressing national tuberculosis program (NTP) for predicating and plan for effective interventional strategies. Tehran University of Medical Sciences 2018-07 /pmc/articles/PMC6119565/ /pubmed/30181996 Text en Copyright© Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
KAZEMPOUR DIZAJI, Mehdi
KAZEMNEJAD, Anoshirvan
TABARSI, Payam
ZAYERI, Farid
Risk Factors Associated with Survival of Pulmonary Tuberculosis
title Risk Factors Associated with Survival of Pulmonary Tuberculosis
title_full Risk Factors Associated with Survival of Pulmonary Tuberculosis
title_fullStr Risk Factors Associated with Survival of Pulmonary Tuberculosis
title_full_unstemmed Risk Factors Associated with Survival of Pulmonary Tuberculosis
title_short Risk Factors Associated with Survival of Pulmonary Tuberculosis
title_sort risk factors associated with survival of pulmonary tuberculosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119565/
https://www.ncbi.nlm.nih.gov/pubmed/30181996
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