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Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway

BACKGROUND: The efficacy of heparins and low-MW-heparins (LMWH) against human asthma has been known for decades. However, the clinical utility of these compounds has been hampered by their anticoagulant properties. Much effort has been put into harnessing the anti-inflammatory properties of LMWH but...

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Detalles Bibliográficos
Autores principales:	Ghonim, Mohamed A., Wang, Jeffrey, Ibba, Salome V., Luu, Hanh H., Pyakurel, Kusma, Benslimane, Ilyes, Mousa, Shaker, Boulares, A. Hamid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119587/ https://www.ncbi.nlm.nih.gov/pubmed/30172259 http://dx.doi.org/10.1186/s12967-018-1621-5

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