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Pediatric lung adenocarcinoma presenting with brain metastasis: a case report
BACKGROUND: Diagnosis and treatment of primary lung adenocarcinoma in children remains challenging given its rarity. Here we highlight the clinical history, pathological evaluation, genomic findings, and management of a very young patient with metastatic lung adenocarcinoma. CASE PRESENTATION: A 10-...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119591/ https://www.ncbi.nlm.nih.gov/pubmed/30172261 http://dx.doi.org/10.1186/s13256-018-1781-1 |
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author | De Martino, Lucia Errico, Maria Elena Ruotolo, Serena Cascone, Daniele Chiaravalli, Stefano Collini, Paola Ferrari, Andrea Muto, Paolo Cinalli, Giuseppe Quaglietta, Lucia |
author_facet | De Martino, Lucia Errico, Maria Elena Ruotolo, Serena Cascone, Daniele Chiaravalli, Stefano Collini, Paola Ferrari, Andrea Muto, Paolo Cinalli, Giuseppe Quaglietta, Lucia |
author_sort | De Martino, Lucia |
collection | PubMed |
description | BACKGROUND: Diagnosis and treatment of primary lung adenocarcinoma in children remains challenging given its rarity. Here we highlight the clinical history, pathological evaluation, genomic findings, and management of a very young patient with metastatic lung adenocarcinoma. CASE PRESENTATION: A 10-year-old white girl presented with brain metastases due to primary pulmonary adenocarcinoma. Next generation sequencing analysis with “Comprehensive Cancer Panel” highlighted the presence of multiple non-targetable mutations in the FLT4, UBR5, ATM, TAF1, and GUCY1A2 genes. She was treated aggressively with chemotherapy, surgery, and radiation therapy for local and distant recurrence. Eventually, therapy with nivolumab was started compassionately, and she died 23 months after diagnosis. CONCLUSIONS: Extremely rare cancers in children such as lung adenocarcinoma need accurate and specific diagnosis in order to develop an optimal plan of treatment. It is also necessary to underline that “children are not little adults,” thus implying that an adult-type cancer in the pediatric population might have a different etiopathogenesis. Diagnostic confirmation and primary treatment of such rare conditions should be centralized in reference centers, collaborative networks, or both, with multidisciplinary approaches and very specific expertise. |
format | Online Article Text |
id | pubmed-6119591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61195912018-09-05 Pediatric lung adenocarcinoma presenting with brain metastasis: a case report De Martino, Lucia Errico, Maria Elena Ruotolo, Serena Cascone, Daniele Chiaravalli, Stefano Collini, Paola Ferrari, Andrea Muto, Paolo Cinalli, Giuseppe Quaglietta, Lucia J Med Case Rep Case Report BACKGROUND: Diagnosis and treatment of primary lung adenocarcinoma in children remains challenging given its rarity. Here we highlight the clinical history, pathological evaluation, genomic findings, and management of a very young patient with metastatic lung adenocarcinoma. CASE PRESENTATION: A 10-year-old white girl presented with brain metastases due to primary pulmonary adenocarcinoma. Next generation sequencing analysis with “Comprehensive Cancer Panel” highlighted the presence of multiple non-targetable mutations in the FLT4, UBR5, ATM, TAF1, and GUCY1A2 genes. She was treated aggressively with chemotherapy, surgery, and radiation therapy for local and distant recurrence. Eventually, therapy with nivolumab was started compassionately, and she died 23 months after diagnosis. CONCLUSIONS: Extremely rare cancers in children such as lung adenocarcinoma need accurate and specific diagnosis in order to develop an optimal plan of treatment. It is also necessary to underline that “children are not little adults,” thus implying that an adult-type cancer in the pediatric population might have a different etiopathogenesis. Diagnostic confirmation and primary treatment of such rare conditions should be centralized in reference centers, collaborative networks, or both, with multidisciplinary approaches and very specific expertise. BioMed Central 2018-09-02 /pmc/articles/PMC6119591/ /pubmed/30172261 http://dx.doi.org/10.1186/s13256-018-1781-1 Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report De Martino, Lucia Errico, Maria Elena Ruotolo, Serena Cascone, Daniele Chiaravalli, Stefano Collini, Paola Ferrari, Andrea Muto, Paolo Cinalli, Giuseppe Quaglietta, Lucia Pediatric lung adenocarcinoma presenting with brain metastasis: a case report |
title | Pediatric lung adenocarcinoma presenting with brain metastasis: a case report |
title_full | Pediatric lung adenocarcinoma presenting with brain metastasis: a case report |
title_fullStr | Pediatric lung adenocarcinoma presenting with brain metastasis: a case report |
title_full_unstemmed | Pediatric lung adenocarcinoma presenting with brain metastasis: a case report |
title_short | Pediatric lung adenocarcinoma presenting with brain metastasis: a case report |
title_sort | pediatric lung adenocarcinoma presenting with brain metastasis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119591/ https://www.ncbi.nlm.nih.gov/pubmed/30172261 http://dx.doi.org/10.1186/s13256-018-1781-1 |
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