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Stage selection for neoadjuvant radiotherapy in non‐cervical esophageal cancer: A propensity score‐matched study based on the SEER database

BACKGROUND: The effect of neoadjuvant radiotherapy (NRT) was controversial in non‐cervical esophageal cancer. The aim of this study was to identify which stage of non‐cervical esophageal cancer would get benefit from NRT using propensity score matching (PSM) and survival analysis based on the Survei...

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Autores principales: Ma, Ke, Yang, Yong, Wang, Shuai, Yang, Xiaodong, Lu, Tao, Xi, Junjie, Jiang, Wei, Zhan, Cheng, Zhu, Yimeng, Wang, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119609/
https://www.ncbi.nlm.nih.gov/pubmed/29961955
http://dx.doi.org/10.1111/1759-7714.12794
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author Ma, Ke
Yang, Yong
Wang, Shuai
Yang, Xiaodong
Lu, Tao
Xi, Junjie
Jiang, Wei
Zhan, Cheng
Zhu, Yimeng
Wang, Qun
author_facet Ma, Ke
Yang, Yong
Wang, Shuai
Yang, Xiaodong
Lu, Tao
Xi, Junjie
Jiang, Wei
Zhan, Cheng
Zhu, Yimeng
Wang, Qun
author_sort Ma, Ke
collection PubMed
description BACKGROUND: The effect of neoadjuvant radiotherapy (NRT) was controversial in non‐cervical esophageal cancer. The aim of this study was to identify which stage of non‐cervical esophageal cancer would get benefit from NRT using propensity score matching (PSM) and survival analysis based on the Surveillance Epidemiology, and End Results (SEER) database. METHODS: A selection process was used for case screening from the SEER database. Seven baseline variables were included in PSM. The survival analysis were based on T stage (T(2) and T(3)) and status of lymph node involvement (N(0) and N(+)) using Kaplan‐Meier method and log‐rank test for comparing the overall survival of patient with NRT plus surgery versus those who with surgery alone (SA). RESULTS: A total of 1631 cases were included in this study. After PSM, 225 cases of esophageal squamous cell carcinoma (ESCC) and 606 cases of esophageal adenocarcinoma (EAC) were enrolled in survival analysis. We found that only T(3)N(+) stage of EAC would got survival benefit from NRT (P = 0.0052), while NRT showed no significant benefit in overall survival in other stages of EAC and ESCC. CONCLUSIONS: NRT followed by resection had a significant survival benefit in non‐cervical EAC patients with T(3)N(+) stage. For patients with ESCC and other EAC stages, NRT versus SA did not demonstrate a statistical significant survival difference.
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spelling pubmed-61196092018-09-05 Stage selection for neoadjuvant radiotherapy in non‐cervical esophageal cancer: A propensity score‐matched study based on the SEER database Ma, Ke Yang, Yong Wang, Shuai Yang, Xiaodong Lu, Tao Xi, Junjie Jiang, Wei Zhan, Cheng Zhu, Yimeng Wang, Qun Thorac Cancer Original Articles BACKGROUND: The effect of neoadjuvant radiotherapy (NRT) was controversial in non‐cervical esophageal cancer. The aim of this study was to identify which stage of non‐cervical esophageal cancer would get benefit from NRT using propensity score matching (PSM) and survival analysis based on the Surveillance Epidemiology, and End Results (SEER) database. METHODS: A selection process was used for case screening from the SEER database. Seven baseline variables were included in PSM. The survival analysis were based on T stage (T(2) and T(3)) and status of lymph node involvement (N(0) and N(+)) using Kaplan‐Meier method and log‐rank test for comparing the overall survival of patient with NRT plus surgery versus those who with surgery alone (SA). RESULTS: A total of 1631 cases were included in this study. After PSM, 225 cases of esophageal squamous cell carcinoma (ESCC) and 606 cases of esophageal adenocarcinoma (EAC) were enrolled in survival analysis. We found that only T(3)N(+) stage of EAC would got survival benefit from NRT (P = 0.0052), while NRT showed no significant benefit in overall survival in other stages of EAC and ESCC. CONCLUSIONS: NRT followed by resection had a significant survival benefit in non‐cervical EAC patients with T(3)N(+) stage. For patients with ESCC and other EAC stages, NRT versus SA did not demonstrate a statistical significant survival difference. John Wiley & Sons Australia, Ltd 2018-07-01 2018-09 /pmc/articles/PMC6119609/ /pubmed/29961955 http://dx.doi.org/10.1111/1759-7714.12794 Text en © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Ma, Ke
Yang, Yong
Wang, Shuai
Yang, Xiaodong
Lu, Tao
Xi, Junjie
Jiang, Wei
Zhan, Cheng
Zhu, Yimeng
Wang, Qun
Stage selection for neoadjuvant radiotherapy in non‐cervical esophageal cancer: A propensity score‐matched study based on the SEER database
title Stage selection for neoadjuvant radiotherapy in non‐cervical esophageal cancer: A propensity score‐matched study based on the SEER database
title_full Stage selection for neoadjuvant radiotherapy in non‐cervical esophageal cancer: A propensity score‐matched study based on the SEER database
title_fullStr Stage selection for neoadjuvant radiotherapy in non‐cervical esophageal cancer: A propensity score‐matched study based on the SEER database
title_full_unstemmed Stage selection for neoadjuvant radiotherapy in non‐cervical esophageal cancer: A propensity score‐matched study based on the SEER database
title_short Stage selection for neoadjuvant radiotherapy in non‐cervical esophageal cancer: A propensity score‐matched study based on the SEER database
title_sort stage selection for neoadjuvant radiotherapy in non‐cervical esophageal cancer: a propensity score‐matched study based on the seer database
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119609/
https://www.ncbi.nlm.nih.gov/pubmed/29961955
http://dx.doi.org/10.1111/1759-7714.12794
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