Cargando…

Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review

Sleep-wake disturbances are common non-motor manifestations in Parkinson Disease (PD). Complex pathophysiological changes secondary to neurodegeneration in combination with motor symptoms and dopaminergic medications contribute to development of sleep-wake disturbances. The management of sleep compl...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharma, Vibhash D., Sengupta, Samarpita, Chitnis, Shilpa, Amara, Amy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119706/
https://www.ncbi.nlm.nih.gov/pubmed/30210429
http://dx.doi.org/10.3389/fneur.2018.00697
_version_ 1783352115997966336
author Sharma, Vibhash D.
Sengupta, Samarpita
Chitnis, Shilpa
Amara, Amy W.
author_facet Sharma, Vibhash D.
Sengupta, Samarpita
Chitnis, Shilpa
Amara, Amy W.
author_sort Sharma, Vibhash D.
collection PubMed
description Sleep-wake disturbances are common non-motor manifestations in Parkinson Disease (PD). Complex pathophysiological changes secondary to neurodegeneration in combination with motor symptoms and dopaminergic medications contribute to development of sleep-wake disturbances. The management of sleep complaints in PD is important as this symptom can affect daily activities and impair quality of life. Deep brain stimulation (DBS) is an effective adjunctive therapy for management of motor symptoms in PD. However, its effect on non-motor symptoms including sleep-wake disturbances is not widely understood. In this article, we reviewed studies assessing the effect of DBS at various therapeutic targets on sleep-wake disturbances. Of the studies examining the role of DBS in sleep-wake disturbances, the effect of subthalamic nucleus stimulation is most widely studied and has shown improvement in sleep quality, sleep efficiency, and sleep duration. Although, studies investigating changes in sleep with stimulation of thalamus, globus pallidus interna, and pedunculopontine nucleus are limited, they support the potential for modulation of sleep-wake centers with DBS at these sites. The mechanism by which DBS at different anatomical targets affects sleep-wake disturbances in PD is unclear and may involves multiple factors, including improved motor symptoms, medication adjustment, and direct modulation of sleep-wake centers.
format Online
Article
Text
id pubmed-6119706
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-61197062018-09-12 Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review Sharma, Vibhash D. Sengupta, Samarpita Chitnis, Shilpa Amara, Amy W. Front Neurol Neurology Sleep-wake disturbances are common non-motor manifestations in Parkinson Disease (PD). Complex pathophysiological changes secondary to neurodegeneration in combination with motor symptoms and dopaminergic medications contribute to development of sleep-wake disturbances. The management of sleep complaints in PD is important as this symptom can affect daily activities and impair quality of life. Deep brain stimulation (DBS) is an effective adjunctive therapy for management of motor symptoms in PD. However, its effect on non-motor symptoms including sleep-wake disturbances is not widely understood. In this article, we reviewed studies assessing the effect of DBS at various therapeutic targets on sleep-wake disturbances. Of the studies examining the role of DBS in sleep-wake disturbances, the effect of subthalamic nucleus stimulation is most widely studied and has shown improvement in sleep quality, sleep efficiency, and sleep duration. Although, studies investigating changes in sleep with stimulation of thalamus, globus pallidus interna, and pedunculopontine nucleus are limited, they support the potential for modulation of sleep-wake centers with DBS at these sites. The mechanism by which DBS at different anatomical targets affects sleep-wake disturbances in PD is unclear and may involves multiple factors, including improved motor symptoms, medication adjustment, and direct modulation of sleep-wake centers. Frontiers Media S.A. 2018-08-27 /pmc/articles/PMC6119706/ /pubmed/30210429 http://dx.doi.org/10.3389/fneur.2018.00697 Text en Copyright © 2018 Sharma, Sengupta, Chitnis and Amara. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Sharma, Vibhash D.
Sengupta, Samarpita
Chitnis, Shilpa
Amara, Amy W.
Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review
title Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review
title_full Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review
title_fullStr Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review
title_full_unstemmed Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review
title_short Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review
title_sort deep brain stimulation and sleep-wake disturbances in parkinson disease: a review
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119706/
https://www.ncbi.nlm.nih.gov/pubmed/30210429
http://dx.doi.org/10.3389/fneur.2018.00697
work_keys_str_mv AT sharmavibhashd deepbrainstimulationandsleepwakedisturbancesinparkinsondiseaseareview
AT senguptasamarpita deepbrainstimulationandsleepwakedisturbancesinparkinsondiseaseareview
AT chitnisshilpa deepbrainstimulationandsleepwakedisturbancesinparkinsondiseaseareview
AT amaraamyw deepbrainstimulationandsleepwakedisturbancesinparkinsondiseaseareview