It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods

Among cyclic nucleotide phosphodiesterases (PDEs), PDE6 is unique in serving as an effector enzyme in G protein-coupled signal transduction. In retinal rods and cones, PDE6 is membrane-bound and activated to hydrolyse its substrate, cGMP, by binding of two active G protein α-subunits (Gα*). To inves...

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Detalles Bibliográficos
Autores principales: Qureshi, Bilal M., Behrmann, Elmar, Schöneberg, Johannes, Loerke, Justus, Bürger, Jörg, Mielke, Thorsten, Giesebrecht, Jan, Noé, Frank, Lamb, Trevor D., Hofmann, Klaus Peter, Spahn, Christian M. T., Heck, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119865/
https://www.ncbi.nlm.nih.gov/pubmed/30068566
http://dx.doi.org/10.1098/rsob.180075

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