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Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway

Nickel (Ni) toxicity has been reported to produce biochemical and behavioral dysfunction. The present study was undertaken to examine whether Ni chronic administration can induce alterations of affective and cognitive behavior and oxidative stress in male and female rats. Twenty-four rats, for each...

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Autores principales: Lamtai, Mouloud, Chaibat, Jihane, Ouakki, Sihame, Zghari, Oussama, Mesfioui, Abdelhalem, El Hessni, Aboubaker, Rifi, El-Housseine, Marmouzi, Ilias, Essamri, Azzouz, Ouichou, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119950/
https://www.ncbi.nlm.nih.gov/pubmed/30065183
http://dx.doi.org/10.3390/brainsci8080141
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author Lamtai, Mouloud
Chaibat, Jihane
Ouakki, Sihame
Zghari, Oussama
Mesfioui, Abdelhalem
El Hessni, Aboubaker
Rifi, El-Housseine
Marmouzi, Ilias
Essamri, Azzouz
Ouichou, Ali
author_facet Lamtai, Mouloud
Chaibat, Jihane
Ouakki, Sihame
Zghari, Oussama
Mesfioui, Abdelhalem
El Hessni, Aboubaker
Rifi, El-Housseine
Marmouzi, Ilias
Essamri, Azzouz
Ouichou, Ali
author_sort Lamtai, Mouloud
collection PubMed
description Nickel (Ni) toxicity has been reported to produce biochemical and behavioral dysfunction. The present study was undertaken to examine whether Ni chronic administration can induce alterations of affective and cognitive behavior and oxidative stress in male and female rats. Twenty-four rats, for each gender, divided into control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or NiCl2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. The Morris Water Maze was used to evaluate the spatial learning and memory. The hippocampus of each animal was taken for biochemical examination. The results showed that Ni administration dose dependently increased anxiety-like behavior in both tests. A significant increase in depression-like symptoms was also exhibited by Ni treated rats. In the Morris Water Maze test, the spatial learning and memory were significantly impaired just in males treated with 1 mg/kg of Ni. With regard to biochemical analysis, activity of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased, while the levels of nitric oxide (NO) and lipid peroxidation (LPO) in the hippocampus were significantly increased in the Ni-treated groups. Consequently, chronic Ni administration induced behavioral and biochemical dysfunctions.
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spelling pubmed-61199502018-09-06 Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway Lamtai, Mouloud Chaibat, Jihane Ouakki, Sihame Zghari, Oussama Mesfioui, Abdelhalem El Hessni, Aboubaker Rifi, El-Housseine Marmouzi, Ilias Essamri, Azzouz Ouichou, Ali Brain Sci Article Nickel (Ni) toxicity has been reported to produce biochemical and behavioral dysfunction. The present study was undertaken to examine whether Ni chronic administration can induce alterations of affective and cognitive behavior and oxidative stress in male and female rats. Twenty-four rats, for each gender, divided into control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or NiCl2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. The Morris Water Maze was used to evaluate the spatial learning and memory. The hippocampus of each animal was taken for biochemical examination. The results showed that Ni administration dose dependently increased anxiety-like behavior in both tests. A significant increase in depression-like symptoms was also exhibited by Ni treated rats. In the Morris Water Maze test, the spatial learning and memory were significantly impaired just in males treated with 1 mg/kg of Ni. With regard to biochemical analysis, activity of catalase (CAT) and superoxide dismutase (SOD) were significantly decreased, while the levels of nitric oxide (NO) and lipid peroxidation (LPO) in the hippocampus were significantly increased in the Ni-treated groups. Consequently, chronic Ni administration induced behavioral and biochemical dysfunctions. MDPI 2018-07-31 /pmc/articles/PMC6119950/ /pubmed/30065183 http://dx.doi.org/10.3390/brainsci8080141 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lamtai, Mouloud
Chaibat, Jihane
Ouakki, Sihame
Zghari, Oussama
Mesfioui, Abdelhalem
El Hessni, Aboubaker
Rifi, El-Housseine
Marmouzi, Ilias
Essamri, Azzouz
Ouichou, Ali
Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway
title Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway
title_full Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway
title_fullStr Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway
title_full_unstemmed Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway
title_short Effect of Chronic Administration of Nickel on Affective and Cognitive Behavior in Male and Female Rats: Possible Implication of Oxidative Stress Pathway
title_sort effect of chronic administration of nickel on affective and cognitive behavior in male and female rats: possible implication of oxidative stress pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119950/
https://www.ncbi.nlm.nih.gov/pubmed/30065183
http://dx.doi.org/10.3390/brainsci8080141
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