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Accelerating High-Throughput Screening for Structural Materials with Production Management Methods

High-throughput screenings are widely accepted for pharmaceutical developments for new substances and the development of new drugs with required characteristics by evolutionary studies. Current research projects transfer this principle of high-throughput testing to the development of metallic materi...

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Autores principales: Bader, Alexander, Meiners, Finn, Tracht, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120044/
https://www.ncbi.nlm.nih.gov/pubmed/30071604
http://dx.doi.org/10.3390/ma11081330
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author Bader, Alexander
Meiners, Finn
Tracht, Kirsten
author_facet Bader, Alexander
Meiners, Finn
Tracht, Kirsten
author_sort Bader, Alexander
collection PubMed
description High-throughput screenings are widely accepted for pharmaceutical developments for new substances and the development of new drugs with required characteristics by evolutionary studies. Current research projects transfer this principle of high-throughput testing to the development of metallic materials. In addition to new generating and testing methods, these types of high-throughput systems need a logistical control and handling method to reduce throughput time to get test results faster. Instead of the direct material flow found in classical high-throughput screenings, these systems have a very complex structure of material flow. The result is a highly dynamic system that includes short-term changes such as rerun stations, partial tests, and temporarily paced sequences between working systems. This paper presents a framework that divides the actions for system acceleration into three main sections. First, methods for special applications in high-throughput systems are designed or adapted to speed up the generation, treatment, and testing processes. Second, methods are needed to process trial plans and to control test orders, which can efficiently reduce waiting times. The third part of the framework describes procedures for handling samples. This reduces non-productive times and reduces order processing in individual lots.
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spelling pubmed-61200442018-09-05 Accelerating High-Throughput Screening for Structural Materials with Production Management Methods Bader, Alexander Meiners, Finn Tracht, Kirsten Materials (Basel) Concept Paper High-throughput screenings are widely accepted for pharmaceutical developments for new substances and the development of new drugs with required characteristics by evolutionary studies. Current research projects transfer this principle of high-throughput testing to the development of metallic materials. In addition to new generating and testing methods, these types of high-throughput systems need a logistical control and handling method to reduce throughput time to get test results faster. Instead of the direct material flow found in classical high-throughput screenings, these systems have a very complex structure of material flow. The result is a highly dynamic system that includes short-term changes such as rerun stations, partial tests, and temporarily paced sequences between working systems. This paper presents a framework that divides the actions for system acceleration into three main sections. First, methods for special applications in high-throughput systems are designed or adapted to speed up the generation, treatment, and testing processes. Second, methods are needed to process trial plans and to control test orders, which can efficiently reduce waiting times. The third part of the framework describes procedures for handling samples. This reduces non-productive times and reduces order processing in individual lots. MDPI 2018-08-01 /pmc/articles/PMC6120044/ /pubmed/30071604 http://dx.doi.org/10.3390/ma11081330 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Concept Paper
Bader, Alexander
Meiners, Finn
Tracht, Kirsten
Accelerating High-Throughput Screening for Structural Materials with Production Management Methods
title Accelerating High-Throughput Screening for Structural Materials with Production Management Methods
title_full Accelerating High-Throughput Screening for Structural Materials with Production Management Methods
title_fullStr Accelerating High-Throughput Screening for Structural Materials with Production Management Methods
title_full_unstemmed Accelerating High-Throughput Screening for Structural Materials with Production Management Methods
title_short Accelerating High-Throughput Screening for Structural Materials with Production Management Methods
title_sort accelerating high-throughput screening for structural materials with production management methods
topic Concept Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120044/
https://www.ncbi.nlm.nih.gov/pubmed/30071604
http://dx.doi.org/10.3390/ma11081330
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