The involvement of osmolarity in the safety of contrast media

BACKGROUND: New non-ionic contrast agents, classified into low osmolar agents and iso-osmolar agents, present different biochemical characteristics that may influence the allergic reactions they cause. The aim of our study was to evaluate how osmolarity may affect safety in the use of contrast agent...

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Detalles Bibliográficos
Autores principales: Isola, Stefania, Furci, Fabiana, Gangemi, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120064/
https://www.ncbi.nlm.nih.gov/pubmed/30186043
http://dx.doi.org/10.1186/s12948-018-0097-4
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author Isola, Stefania
Furci, Fabiana
Gangemi, Sebastiano
author_facet Isola, Stefania
Furci, Fabiana
Gangemi, Sebastiano
author_sort Isola, Stefania
collection PubMed
description BACKGROUND: New non-ionic contrast agents, classified into low osmolar agents and iso-osmolar agents, present different biochemical characteristics that may influence the allergic reactions they cause. The aim of our study was to evaluate how osmolarity may affect safety in the use of contrast agents. CASE PRESENTATION: Six patients with a positive history for reaction to contrast agent were included in this study. Only one patient prick and intradermal skin test was positive. However, in 5 cases, patients presented an immediate reaction after administration of contrast agent that was not IgE mediated. CONCLUSIONS: In this study, we focused on iodixanol, an iso-osmolar contrast agent, finding good safety of this product in patients with previous hypersensitivity reactions to contrast agent.
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spelling pubmed-61200642018-09-05 The involvement of osmolarity in the safety of contrast media Isola, Stefania Furci, Fabiana Gangemi, Sebastiano Clin Mol Allergy Case Report BACKGROUND: New non-ionic contrast agents, classified into low osmolar agents and iso-osmolar agents, present different biochemical characteristics that may influence the allergic reactions they cause. The aim of our study was to evaluate how osmolarity may affect safety in the use of contrast agents. CASE PRESENTATION: Six patients with a positive history for reaction to contrast agent were included in this study. Only one patient prick and intradermal skin test was positive. However, in 5 cases, patients presented an immediate reaction after administration of contrast agent that was not IgE mediated. CONCLUSIONS: In this study, we focused on iodixanol, an iso-osmolar contrast agent, finding good safety of this product in patients with previous hypersensitivity reactions to contrast agent. BioMed Central 2018-09-03 /pmc/articles/PMC6120064/ /pubmed/30186043 http://dx.doi.org/10.1186/s12948-018-0097-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Isola, Stefania
Furci, Fabiana
Gangemi, Sebastiano
The involvement of osmolarity in the safety of contrast media
title The involvement of osmolarity in the safety of contrast media
title_full The involvement of osmolarity in the safety of contrast media
title_fullStr The involvement of osmolarity in the safety of contrast media
title_full_unstemmed The involvement of osmolarity in the safety of contrast media
title_short The involvement of osmolarity in the safety of contrast media
title_sort involvement of osmolarity in the safety of contrast media
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120064/
https://www.ncbi.nlm.nih.gov/pubmed/30186043
http://dx.doi.org/10.1186/s12948-018-0097-4
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