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LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs)

Volume-regulated anion channels (VRACs) are crucial for cell volume regulation and have various roles in physiology and pathology. VRACs were recently discovered to be formed by heteromers of leucine-rich repeat–containing 8 (LRRC8) proteins. However, the structural determinants of VRAC permeation a...

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Detalles Bibliográficos
Autores principales:	Zhou, Pingzheng, Polovitskaya, Maya M., Jentsch, Thomas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120214/ https://www.ncbi.nlm.nih.gov/pubmed/29925591 http://dx.doi.org/10.1074/jbc.RA118.002853

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