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Three human aminoacyl-tRNA synthetases have distinct sub-mitochondrial localizations that are unaffected by disease-associated mutations

Human mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) are key enzymes in the mitochondrial protein translation system and catalyze the charging of amino acids on their cognate tRNAs. Mutations in their nuclear genes are associated with pathologies having a broad spectrum of clinical phenotypes,...

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Detalles Bibliográficos
Autores principales:	González-Serrano, Ligia Elena, Karim, Loukmane, Pierre, Florian, Schwenzer, Hagen, Rötig, Agnès, Munnich, Arnold, Sissler, Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Protein Synthesis and Degradation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120215/ https://www.ncbi.nlm.nih.gov/pubmed/30006346 http://dx.doi.org/10.1074/jbc.RA118.003400

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