Identification of inactive conformation‐selective interleukin‐2‐inducible T‐cell kinase (ITK) inhibitors based on second‐harmonic generation

Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inhibitors that stabilize an inactive conformation ar...

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Detalles Bibliográficos
Autores principales: Hantani, Yoshiji, Iio, Kiyosei, Hantani, Rie, Umetani, Kayo, Sato, Toshihiro, Young, Tracy, Connell, Katelyn, Kintz, Sam, Salafsky, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120236/
https://www.ncbi.nlm.nih.gov/pubmed/30186743
http://dx.doi.org/10.1002/2211-5463.12489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120236/
https://www.ncbi.nlm.nih.gov/pubmed/30186743
http://dx.doi.org/10.1002/2211-5463.12489

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