A stable association with PME‐1 may be dispensable for PP2A demethylation – implications for the detection of PP2A methylation and immunoprecipitation

Reversible methyl‐esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme. Accumulating evidence links PP2Ac methylation to diseases, including cancer and neurodegenerative disorders. Protein phosphatase...

Descripción completa

Detalles Bibliográficos
Autores principales: Yabe, Ryotaro, Tsuji, Shunya, Mochida, Satoru, Ikehara, Tsuyoshi, Usui, Tatsuya, Ohama, Takashi, Sato, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120246/
https://www.ncbi.nlm.nih.gov/pubmed/30186749
http://dx.doi.org/10.1002/2211-5463.12485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120246/
https://www.ncbi.nlm.nih.gov/pubmed/30186749
http://dx.doi.org/10.1002/2211-5463.12485

Ejemplares similares