Cargando…
Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local a...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120281/ https://www.ncbi.nlm.nih.gov/pubmed/30210571 http://dx.doi.org/10.1155/2018/3610494 |
_version_ | 1783352239840034816 |
---|---|
author | Lee, Song Yi Nam, Suyeong Kim, Sungyun Koo, Ja Seong Hong, In Kee Kim, Hill Han, Sangin Kang, Minji Yang, Heejung Cho, Hyun-Jong |
author_facet | Lee, Song Yi Nam, Suyeong Kim, Sungyun Koo, Ja Seong Hong, In Kee Kim, Hill Han, Sangin Kang, Minji Yang, Heejung Cho, Hyun-Jong |
author_sort | Lee, Song Yi |
collection | PubMed |
description | A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 (p < 0.05). The results of the hematoxylin and eosin staining of skin tissues revealed that the epidermal thickness value of the IMQ + ACE cream group was significantly lower than those of the other experimental groups (p < 0.05). The expression level of intracellular adhesion molecule-1 (ICAM-1), which indicates the leukocyte infiltration into the skin and subsequent interactions with keratinocytes, was also lower in the IMQ + ACE cream group than in the IMQ group. These results indicate that ACE cream formulation could be used safely and conveniently for psoriasis treatment. |
format | Online Article Text |
id | pubmed-6120281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61202812018-09-12 Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models Lee, Song Yi Nam, Suyeong Kim, Sungyun Koo, Ja Seong Hong, In Kee Kim, Hill Han, Sangin Kang, Minji Yang, Heejung Cho, Hyun-Jong Evid Based Complement Alternat Med Research Article A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 (p < 0.05). The results of the hematoxylin and eosin staining of skin tissues revealed that the epidermal thickness value of the IMQ + ACE cream group was significantly lower than those of the other experimental groups (p < 0.05). The expression level of intracellular adhesion molecule-1 (ICAM-1), which indicates the leukocyte infiltration into the skin and subsequent interactions with keratinocytes, was also lower in the IMQ + ACE cream group than in the IMQ group. These results indicate that ACE cream formulation could be used safely and conveniently for psoriasis treatment. Hindawi 2018-08-19 /pmc/articles/PMC6120281/ /pubmed/30210571 http://dx.doi.org/10.1155/2018/3610494 Text en Copyright © 2018 Song Yi Lee et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lee, Song Yi Nam, Suyeong Kim, Sungyun Koo, Ja Seong Hong, In Kee Kim, Hill Han, Sangin Kang, Minji Yang, Heejung Cho, Hyun-Jong Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title | Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_full | Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_fullStr | Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_full_unstemmed | Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_short | Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_sort | therapeutic efficacies of artemisia capillaris extract cream formulation in imiquimod-induced psoriasis models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120281/ https://www.ncbi.nlm.nih.gov/pubmed/30210571 http://dx.doi.org/10.1155/2018/3610494 |
work_keys_str_mv | AT leesongyi therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT namsuyeong therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT kimsungyun therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT koojaseong therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT honginkee therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT kimhill therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT hansangin therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT kangminji therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT yangheejung therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT chohyunjong therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels |