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Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models

A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local a...

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Autores principales: Lee, Song Yi, Nam, Suyeong, Kim, Sungyun, Koo, Ja Seong, Hong, In Kee, Kim, Hill, Han, Sangin, Kang, Minji, Yang, Heejung, Cho, Hyun-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120281/
https://www.ncbi.nlm.nih.gov/pubmed/30210571
http://dx.doi.org/10.1155/2018/3610494
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author Lee, Song Yi
Nam, Suyeong
Kim, Sungyun
Koo, Ja Seong
Hong, In Kee
Kim, Hill
Han, Sangin
Kang, Minji
Yang, Heejung
Cho, Hyun-Jong
author_facet Lee, Song Yi
Nam, Suyeong
Kim, Sungyun
Koo, Ja Seong
Hong, In Kee
Kim, Hill
Han, Sangin
Kang, Minji
Yang, Heejung
Cho, Hyun-Jong
author_sort Lee, Song Yi
collection PubMed
description A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 (p < 0.05). The results of the hematoxylin and eosin staining of skin tissues revealed that the epidermal thickness value of the IMQ + ACE cream group was significantly lower than those of the other experimental groups (p < 0.05). The expression level of intracellular adhesion molecule-1 (ICAM-1), which indicates the leukocyte infiltration into the skin and subsequent interactions with keratinocytes, was also lower in the IMQ + ACE cream group than in the IMQ group. These results indicate that ACE cream formulation could be used safely and conveniently for psoriasis treatment.
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spelling pubmed-61202812018-09-12 Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models Lee, Song Yi Nam, Suyeong Kim, Sungyun Koo, Ja Seong Hong, In Kee Kim, Hill Han, Sangin Kang, Minji Yang, Heejung Cho, Hyun-Jong Evid Based Complement Alternat Med Research Article A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 (p < 0.05). The results of the hematoxylin and eosin staining of skin tissues revealed that the epidermal thickness value of the IMQ + ACE cream group was significantly lower than those of the other experimental groups (p < 0.05). The expression level of intracellular adhesion molecule-1 (ICAM-1), which indicates the leukocyte infiltration into the skin and subsequent interactions with keratinocytes, was also lower in the IMQ + ACE cream group than in the IMQ group. These results indicate that ACE cream formulation could be used safely and conveniently for psoriasis treatment. Hindawi 2018-08-19 /pmc/articles/PMC6120281/ /pubmed/30210571 http://dx.doi.org/10.1155/2018/3610494 Text en Copyright © 2018 Song Yi Lee et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lee, Song Yi
Nam, Suyeong
Kim, Sungyun
Koo, Ja Seong
Hong, In Kee
Kim, Hill
Han, Sangin
Kang, Minji
Yang, Heejung
Cho, Hyun-Jong
Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
title Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
title_full Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
title_fullStr Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
title_full_unstemmed Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
title_short Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
title_sort therapeutic efficacies of artemisia capillaris extract cream formulation in imiquimod-induced psoriasis models
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120281/
https://www.ncbi.nlm.nih.gov/pubmed/30210571
http://dx.doi.org/10.1155/2018/3610494
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