Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn's Disease Treated with Immunosuppressive Therapy

We report a case of acute myeloid leukemia with myelodysplasia-related changes in a patient with Crohn's disease. The patient was diagnosed with Crohn's disease at the age of 47 years and was treated with the tumor necrosis factor α inhibitors adalimumab and infliximab, and a short course...

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Detalles Bibliográficos
Autores principales: Li, Bowen, Zhu, Zhenhua, Long, Shunhua, Li, Fei, Zhu, Xuan, Liao, Wangdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120370/
https://www.ncbi.nlm.nih.gov/pubmed/30186142
http://dx.doi.org/10.1159/000491573
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author Li, Bowen
Zhu, Zhenhua
Long, Shunhua
Li, Fei
Zhu, Xuan
Liao, Wangdi
author_facet Li, Bowen
Zhu, Zhenhua
Long, Shunhua
Li, Fei
Zhu, Xuan
Liao, Wangdi
author_sort Li, Bowen
collection PubMed
description We report a case of acute myeloid leukemia with myelodysplasia-related changes in a patient with Crohn's disease. The patient was diagnosed with Crohn's disease at the age of 47 years and was treated with the tumor necrosis factor α inhibitors adalimumab and infliximab, and a short course of azathioprine. Four years later, the patient developed acute myeloid leukemia with myelodysplasia that involved mainly erythropoiesis. Crohn's disease is associated with an increased risk of cancers including hematological malignancies. Cancer surveillance including hematology assessment is warranted to monitor the patients on immunosuppressive therapy.
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spelling pubmed-61203702018-09-05 Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn's Disease Treated with Immunosuppressive Therapy Li, Bowen Zhu, Zhenhua Long, Shunhua Li, Fei Zhu, Xuan Liao, Wangdi Case Rep Oncol Case Report We report a case of acute myeloid leukemia with myelodysplasia-related changes in a patient with Crohn's disease. The patient was diagnosed with Crohn's disease at the age of 47 years and was treated with the tumor necrosis factor α inhibitors adalimumab and infliximab, and a short course of azathioprine. Four years later, the patient developed acute myeloid leukemia with myelodysplasia that involved mainly erythropoiesis. Crohn's disease is associated with an increased risk of cancers including hematological malignancies. Cancer surveillance including hematology assessment is warranted to monitor the patients on immunosuppressive therapy. S. Karger AG 2018-08-17 /pmc/articles/PMC6120370/ /pubmed/30186142 http://dx.doi.org/10.1159/000491573 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Li, Bowen
Zhu, Zhenhua
Long, Shunhua
Li, Fei
Zhu, Xuan
Liao, Wangdi
Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn's Disease Treated with Immunosuppressive Therapy
title Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn's Disease Treated with Immunosuppressive Therapy
title_full Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn's Disease Treated with Immunosuppressive Therapy
title_fullStr Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn's Disease Treated with Immunosuppressive Therapy
title_full_unstemmed Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn's Disease Treated with Immunosuppressive Therapy
title_short Acute Myeloid Leukemia with Myelodysplasia-Related Changes in a Patient with Crohn's Disease Treated with Immunosuppressive Therapy
title_sort acute myeloid leukemia with myelodysplasia-related changes in a patient with crohn's disease treated with immunosuppressive therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120370/
https://www.ncbi.nlm.nih.gov/pubmed/30186142
http://dx.doi.org/10.1159/000491573
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