Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions

A transition metal‐free N‐arylation of primary and secondary amines with diaryliodonium salts is presented. Both acyclic and cyclic amines are well tolerated, providing a large set of N‐alkyl anilines. The methodology is unprecedented among metal‐free methods in terms of amine scope, the ability to...

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Autores principales: Purkait, Nibadita, Kervefors, Gabriella, Linde, Erika, Olofsson, Berit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120470/
https://www.ncbi.nlm.nih.gov/pubmed/29956877
http://dx.doi.org/10.1002/anie.201807001
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author Purkait, Nibadita
Kervefors, Gabriella
Linde, Erika
Olofsson, Berit
author_facet Purkait, Nibadita
Kervefors, Gabriella
Linde, Erika
Olofsson, Berit
author_sort Purkait, Nibadita
collection PubMed
description A transition metal‐free N‐arylation of primary and secondary amines with diaryliodonium salts is presented. Both acyclic and cyclic amines are well tolerated, providing a large set of N‐alkyl anilines. The methodology is unprecedented among metal‐free methods in terms of amine scope, the ability to transfer both electron‐withdrawing and electron‐donating aryl groups, and efficient use of resources, as excess substrate or reagents are not required.
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spelling pubmed-61204702018-09-05 Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions Purkait, Nibadita Kervefors, Gabriella Linde, Erika Olofsson, Berit Angew Chem Int Ed Engl Communications A transition metal‐free N‐arylation of primary and secondary amines with diaryliodonium salts is presented. Both acyclic and cyclic amines are well tolerated, providing a large set of N‐alkyl anilines. The methodology is unprecedented among metal‐free methods in terms of amine scope, the ability to transfer both electron‐withdrawing and electron‐donating aryl groups, and efficient use of resources, as excess substrate or reagents are not required. John Wiley and Sons Inc. 2018-07-26 2018-08-27 /pmc/articles/PMC6120470/ /pubmed/29956877 http://dx.doi.org/10.1002/anie.201807001 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Purkait, Nibadita
Kervefors, Gabriella
Linde, Erika
Olofsson, Berit
Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions
title Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions
title_full Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions
title_fullStr Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions
title_full_unstemmed Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions
title_short Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions
title_sort regiospecific n‐arylation of aliphatic amines under mild and metal‐free reaction conditions
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120470/
https://www.ncbi.nlm.nih.gov/pubmed/29956877
http://dx.doi.org/10.1002/anie.201807001
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