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Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin

BACKGROUND & AIMS: Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe(2+) from the iron exporter ferroportin 1 for delivery to the circulating Fe(3+) carrier transferrin. Hephaestin (HEPH), the...

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Detalles Bibliográficos
Autores principales:	Fuqua, Brie K., Lu, Yan, Frazer, David M., Darshan, Deepak, Wilkins, Sarah J., Dunn, Linda, Loguinov, Alex V., Kogan, Scott C., Matak, Pavle, Chen, Huijun, Dunaief, Joshua L., Vulpe, Chris D., Anderson, Gregory J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120670/ https://www.ncbi.nlm.nih.gov/pubmed/30182051 http://dx.doi.org/10.1016/j.jcmgh.2018.06.006

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