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Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer

Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER(+) breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and un...

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Detalles Bibliográficos
Autores principales: Siersbæk, Rasmus, Kumar, Sanjeev, Carroll, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120708/
https://www.ncbi.nlm.nih.gov/pubmed/30181360
http://dx.doi.org/10.1101/gad.316646.118
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author Siersbæk, Rasmus
Kumar, Sanjeev
Carroll, Jason S.
author_facet Siersbæk, Rasmus
Kumar, Sanjeev
Carroll, Jason S.
author_sort Siersbæk, Rasmus
collection PubMed
description Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER(+) breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mechanisms leading to drug resistance is consequently of utmost importance. It is now clear that, in addition to estrogens, ER function is modulated by other steroid receptors and multiple signaling pathways (e.g., growth factor and cytokine signaling), and many of these pathways affect drug resistance and patient outcome. Here, we review the mechanisms through which these pathways impact ER function and drug resistance as well as discuss the clinical implications.
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spelling pubmed-61207082019-03-01 Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer Siersbæk, Rasmus Kumar, Sanjeev Carroll, Jason S. Genes Dev Review Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER(+) breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mechanisms leading to drug resistance is consequently of utmost importance. It is now clear that, in addition to estrogens, ER function is modulated by other steroid receptors and multiple signaling pathways (e.g., growth factor and cytokine signaling), and many of these pathways affect drug resistance and patient outcome. Here, we review the mechanisms through which these pathways impact ER function and drug resistance as well as discuss the clinical implications. Cold Spring Harbor Laboratory Press 2018-09-01 /pmc/articles/PMC6120708/ /pubmed/30181360 http://dx.doi.org/10.1101/gad.316646.118 Text en © 2018 Siersbæk et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Siersbæk, Rasmus
Kumar, Sanjeev
Carroll, Jason S.
Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer
title Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer
title_full Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer
title_fullStr Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer
title_full_unstemmed Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer
title_short Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer
title_sort signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120708/
https://www.ncbi.nlm.nih.gov/pubmed/30181360
http://dx.doi.org/10.1101/gad.316646.118
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