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Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer
Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER(+) breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and un...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120708/ https://www.ncbi.nlm.nih.gov/pubmed/30181360 http://dx.doi.org/10.1101/gad.316646.118 |
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author | Siersbæk, Rasmus Kumar, Sanjeev Carroll, Jason S. |
author_facet | Siersbæk, Rasmus Kumar, Sanjeev Carroll, Jason S. |
author_sort | Siersbæk, Rasmus |
collection | PubMed |
description | Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER(+) breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mechanisms leading to drug resistance is consequently of utmost importance. It is now clear that, in addition to estrogens, ER function is modulated by other steroid receptors and multiple signaling pathways (e.g., growth factor and cytokine signaling), and many of these pathways affect drug resistance and patient outcome. Here, we review the mechanisms through which these pathways impact ER function and drug resistance as well as discuss the clinical implications. |
format | Online Article Text |
id | pubmed-6120708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61207082019-03-01 Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer Siersbæk, Rasmus Kumar, Sanjeev Carroll, Jason S. Genes Dev Review Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER(+) breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mechanisms leading to drug resistance is consequently of utmost importance. It is now clear that, in addition to estrogens, ER function is modulated by other steroid receptors and multiple signaling pathways (e.g., growth factor and cytokine signaling), and many of these pathways affect drug resistance and patient outcome. Here, we review the mechanisms through which these pathways impact ER function and drug resistance as well as discuss the clinical implications. Cold Spring Harbor Laboratory Press 2018-09-01 /pmc/articles/PMC6120708/ /pubmed/30181360 http://dx.doi.org/10.1101/gad.316646.118 Text en © 2018 Siersbæk et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Siersbæk, Rasmus Kumar, Sanjeev Carroll, Jason S. Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer |
title | Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer |
title_full | Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer |
title_fullStr | Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer |
title_full_unstemmed | Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer |
title_short | Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer |
title_sort | signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120708/ https://www.ncbi.nlm.nih.gov/pubmed/30181360 http://dx.doi.org/10.1101/gad.316646.118 |
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