Anti-PL-7 Antisynthetase Syndrome with Eosinophilic Pleural Effusion

A 68-year-old woman was admitted to our hospital with fever and pleural effusion. Her thoracentesis showed eosinophilic pleural effusion (EPE) without any evidence of malignancy, infection, or trauma. Pleural biopsy revealed pleuritis and intercostal myositis. Characteristic skin manifestations, inc...

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Detalles Bibliográficos
Autores principales: Saito, Go, Kono, Masato, Tsutsumi, Akari, Koyanagi, Yu, Miyashita, Koichi, Kobayashi, Takeshi, Hozumi, Hironao, Miki, Yoshihiro, Arai, Yoshifumi, Otsuki, Yoshiro, Hashimoto, Dai, Fujisawa, Tomoyuki, Nakamura, Toru, Suda, Takafumi, Nakamura, Hidenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120831/
https://www.ncbi.nlm.nih.gov/pubmed/29526945
http://dx.doi.org/10.2169/internalmedicine.0302-17
Descripción
Sumario:A 68-year-old woman was admitted to our hospital with fever and pleural effusion. Her thoracentesis showed eosinophilic pleural effusion (EPE) without any evidence of malignancy, infection, or trauma. Pleural biopsy revealed pleuritis and intercostal myositis. Characteristic skin manifestations, including Gottron's sign, interstitial lung disease, and pericardial effusion, appeared later in the clinical course. She was finally diagnosed with anti-PL-7 antisynthetase syndrome (ASS) based on the presence of anti-PL-7 antibody, and she fulfilled the diagnostic criteria for dermatomyositis. These clinical manifestations improved with immunosuppressive therapy. EPE might therefore be one of the characteristic features of anti-PL-7 ASS.

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