Chirality and structure-selective MALDI using mold matrix

A matrix that enabled chirality and structure-selective detection in matrix assisted laser desorption ionization mass spectrometry (MALDI MS) has been developed. Molds of L- or D- alanine were made on a thermoreversible polymer (polyvinyl methyl ether) with 2,4,6-trihydroxyacetophenone, and this was...

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Autores principales: Fujii, Yosuke, Xu, Jiawei, Fujino, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120879/
https://www.ncbi.nlm.nih.gov/pubmed/30177702
http://dx.doi.org/10.1038/s41598-018-31629-6
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author Fujii, Yosuke
Xu, Jiawei
Fujino, Tatsuya
author_facet Fujii, Yosuke
Xu, Jiawei
Fujino, Tatsuya
author_sort Fujii, Yosuke
collection PubMed
description A matrix that enabled chirality and structure-selective detection in matrix assisted laser desorption ionization mass spectrometry (MALDI MS) has been developed. Molds of L- or D- alanine were made on a thermoreversible polymer (polyvinyl methyl ether) with 2,4,6-trihydroxyacetophenone, and this was used as a matrix. Separate detection of one optical isomer of alanine was realized in MALDI MS. This technique was also applied to the detection of trisaccharides having the same molecular weight but different structures. Separate detection of raffinose and maltotriose in MALDI MS were presented.
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spelling pubmed-61208792018-09-06 Chirality and structure-selective MALDI using mold matrix Fujii, Yosuke Xu, Jiawei Fujino, Tatsuya Sci Rep Article A matrix that enabled chirality and structure-selective detection in matrix assisted laser desorption ionization mass spectrometry (MALDI MS) has been developed. Molds of L- or D- alanine were made on a thermoreversible polymer (polyvinyl methyl ether) with 2,4,6-trihydroxyacetophenone, and this was used as a matrix. Separate detection of one optical isomer of alanine was realized in MALDI MS. This technique was also applied to the detection of trisaccharides having the same molecular weight but different structures. Separate detection of raffinose and maltotriose in MALDI MS were presented. Nature Publishing Group UK 2018-09-03 /pmc/articles/PMC6120879/ /pubmed/30177702 http://dx.doi.org/10.1038/s41598-018-31629-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Fujii, Yosuke
Xu, Jiawei
Fujino, Tatsuya
Chirality and structure-selective MALDI using mold matrix
title Chirality and structure-selective MALDI using mold matrix
title_full Chirality and structure-selective MALDI using mold matrix
title_fullStr Chirality and structure-selective MALDI using mold matrix
title_full_unstemmed Chirality and structure-selective MALDI using mold matrix
title_short Chirality and structure-selective MALDI using mold matrix
title_sort chirality and structure-selective maldi using mold matrix
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120879/
https://www.ncbi.nlm.nih.gov/pubmed/30177702
http://dx.doi.org/10.1038/s41598-018-31629-6
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AT fujinotatsuya chiralityandstructureselectivemaldiusingmoldmatrix

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