Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

The gene encoding the transcription factor TFAP4/AP4 represents a direct target of the c-MYC oncoprotein. Here, we deleted Ap4 in Apc(Min) mice, a preclinical model of inherited colorectal cancer. Ap4 deficiency extends their average survival by 110 days and decreases the formation of intestinal ade...

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Detalles Bibliográficos
Autores principales: Jaeckel, Stephanie, Kaller, Markus, Jackstadt, Rene, Götz, Ursula, Müller, Susanna, Boos, Sophie, Horst, David, Jung, Peter, Hermeking, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120921/
https://www.ncbi.nlm.nih.gov/pubmed/30177706
http://dx.doi.org/10.1038/s41467-018-06001-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120921/
https://www.ncbi.nlm.nih.gov/pubmed/30177706
http://dx.doi.org/10.1038/s41467-018-06001-x

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