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Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells
The gene encoding the transcription factor TFAP4/AP4 represents a direct target of the c-MYC oncoprotein. Here, we deleted Ap4 in Apc(Min) mice, a preclinical model of inherited colorectal cancer. Ap4 deficiency extends their average survival by 110 days and decreases the formation of intestinal ade...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120921/ https://www.ncbi.nlm.nih.gov/pubmed/30177706 http://dx.doi.org/10.1038/s41467-018-06001-x |