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Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis

Tuberculosis (TB) remains a leading cause of fatal infectious disease. Accumulations of macrophages are found in infected sites; thus, we hypothesized that a marker of activated macrophages may be related to prognosis of pulmonary TB (PTB). This study investigated serum soluble macrophage mannose re...

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Autores principales: Suzuki, Yuzo, Shirai, Masahiro, Asada, Kazuhiro, Yasui, Hideki, Karayama, Masato, Hozumi, Hironao, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Inui, Naoki, Shirai, Toshihiro, Hayakawa, Hiroshi, Suda, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120933/
https://www.ncbi.nlm.nih.gov/pubmed/30177769
http://dx.doi.org/10.1038/s41598-018-31565-5
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author Suzuki, Yuzo
Shirai, Masahiro
Asada, Kazuhiro
Yasui, Hideki
Karayama, Masato
Hozumi, Hironao
Furuhashi, Kazuki
Enomoto, Noriyuki
Fujisawa, Tomoyuki
Nakamura, Yutaro
Inui, Naoki
Shirai, Toshihiro
Hayakawa, Hiroshi
Suda, Takafumi
author_facet Suzuki, Yuzo
Shirai, Masahiro
Asada, Kazuhiro
Yasui, Hideki
Karayama, Masato
Hozumi, Hironao
Furuhashi, Kazuki
Enomoto, Noriyuki
Fujisawa, Tomoyuki
Nakamura, Yutaro
Inui, Naoki
Shirai, Toshihiro
Hayakawa, Hiroshi
Suda, Takafumi
author_sort Suzuki, Yuzo
collection PubMed
description Tuberculosis (TB) remains a leading cause of fatal infectious disease. Accumulations of macrophages are found in infected sites; thus, we hypothesized that a marker of activated macrophages may be related to prognosis of pulmonary TB (PTB). This study investigated serum soluble macrophage mannose receptor, sCD206, in PTB and examined its clinical significance. First, the concentration of sCD206 was measured in the sera of 96 patients with PTB (Tenryu cohort), and in pleural effusions from 29 patients with TB pleurisy. These were verified in another independent cohort (Shizuoka cohort). We found increased concentrations of sCD206 in sera, but not in pleural effusions of PTB patients. Notably, PTB patients with poor prognosis showed significantly higher levels of serum sCD206. At a cut-off value of 1,600 ng/mL in the Tenryu cohort, sCD206 predicted prognosis of PTB with area under the curve 0.847, sensitivity 77.3%, and specificity 86.5%. These results were validated in the Shizuoka cohort. Pathological analyses showed concordance of enhanced CD206 expression in lung and pleural tissues with caseating granuloma in TB. Serum sCD206 increased in PTB and was associated with prognosis. sCD206 is a potential biomarker for PTB.
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spelling pubmed-61209332018-09-06 Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis Suzuki, Yuzo Shirai, Masahiro Asada, Kazuhiro Yasui, Hideki Karayama, Masato Hozumi, Hironao Furuhashi, Kazuki Enomoto, Noriyuki Fujisawa, Tomoyuki Nakamura, Yutaro Inui, Naoki Shirai, Toshihiro Hayakawa, Hiroshi Suda, Takafumi Sci Rep Article Tuberculosis (TB) remains a leading cause of fatal infectious disease. Accumulations of macrophages are found in infected sites; thus, we hypothesized that a marker of activated macrophages may be related to prognosis of pulmonary TB (PTB). This study investigated serum soluble macrophage mannose receptor, sCD206, in PTB and examined its clinical significance. First, the concentration of sCD206 was measured in the sera of 96 patients with PTB (Tenryu cohort), and in pleural effusions from 29 patients with TB pleurisy. These were verified in another independent cohort (Shizuoka cohort). We found increased concentrations of sCD206 in sera, but not in pleural effusions of PTB patients. Notably, PTB patients with poor prognosis showed significantly higher levels of serum sCD206. At a cut-off value of 1,600 ng/mL in the Tenryu cohort, sCD206 predicted prognosis of PTB with area under the curve 0.847, sensitivity 77.3%, and specificity 86.5%. These results were validated in the Shizuoka cohort. Pathological analyses showed concordance of enhanced CD206 expression in lung and pleural tissues with caseating granuloma in TB. Serum sCD206 increased in PTB and was associated with prognosis. sCD206 is a potential biomarker for PTB. Nature Publishing Group UK 2018-09-03 /pmc/articles/PMC6120933/ /pubmed/30177769 http://dx.doi.org/10.1038/s41598-018-31565-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Suzuki, Yuzo
Shirai, Masahiro
Asada, Kazuhiro
Yasui, Hideki
Karayama, Masato
Hozumi, Hironao
Furuhashi, Kazuki
Enomoto, Noriyuki
Fujisawa, Tomoyuki
Nakamura, Yutaro
Inui, Naoki
Shirai, Toshihiro
Hayakawa, Hiroshi
Suda, Takafumi
Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_full Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_fullStr Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_full_unstemmed Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_short Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_sort macrophage mannose receptor, cd206, predict prognosis in patients with pulmonary tuberculosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120933/
https://www.ncbi.nlm.nih.gov/pubmed/30177769
http://dx.doi.org/10.1038/s41598-018-31565-5
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