Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects

Calpain hyperactivation is implicated in late-stages of neurodegenerative diseases including Alzheimer’s disease (AD). However, calpains are also critical for synaptic function and plasticity, and hence memory formation and learning. Since synaptic deficits appear early in AD pathogenesis prior to a...

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Detalles Bibliográficos
Autores principales: Ahmad, Faraz, Das, Debajyoti, Kommaddi, Reddy Peera, Diwakar, Latha, Gowaikar, Ruturaj, Rupanagudi, Khader Valli, Bennett, David A., Ravindranath, Vijayalakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120938/
https://www.ncbi.nlm.nih.gov/pubmed/30177812
http://dx.doi.org/10.1038/s41598-018-31073-6

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