A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5(+) intestinal stem cell maintenance

Lgr5(+) intestinal stem cells (ISCs) drive the fast renewal of intestinal epithelium. Several signaling pathways have been shown to regulate ISC fates. However, it is unclear what are the essential signals to sustain the ISC self-renewal. Here we show that coordination between Wnt and BMP signaling...

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Detalles Bibliográficos
Autores principales: Li, Yehua, Liu, Yuan, Liu, Bofeng, Wang, Jilian, Wei, Siting, Qi, Zhen, Wang, Shan, Fu, Wei, Chen, Ye-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120946/
https://www.ncbi.nlm.nih.gov/pubmed/30181900
http://dx.doi.org/10.1038/s41421-018-0051-0

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