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Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction

Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of cardiac function, and congestive heart failure. Whil...

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Autores principales: Prabhat, Anjali M., Kuppusamy, M. Lakshmi, Naidu, Shan K., Meduru, Sarath, Reddy, Praneeth T., Dominic, Abishai, Khan, Mahmood, Rivera, Brian K., Kuppusamy, Periannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120988/
https://www.ncbi.nlm.nih.gov/pubmed/30211171
http://dx.doi.org/10.3389/fcvm.2018.00114
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author Prabhat, Anjali M.
Kuppusamy, M. Lakshmi
Naidu, Shan K.
Meduru, Sarath
Reddy, Praneeth T.
Dominic, Abishai
Khan, Mahmood
Rivera, Brian K.
Kuppusamy, Periannan
author_facet Prabhat, Anjali M.
Kuppusamy, M. Lakshmi
Naidu, Shan K.
Meduru, Sarath
Reddy, Praneeth T.
Dominic, Abishai
Khan, Mahmood
Rivera, Brian K.
Kuppusamy, Periannan
author_sort Prabhat, Anjali M.
collection PubMed
description Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of cardiac function, and congestive heart failure. While supplemental oxygen therapy has long been in practice to treat acute MI, there has not been a clear scientific basis for the observed beneficial effects. Further, there is no rationale for the amount or duration of administration of supplemental oxygenation for effective therapy. The goal of the present study was to determine an optimum oxygenation protocol that can be clinically applicable for treating acute MI. Using EPR oximetry, we studied the effect of exposure to supplemental oxygen cycling (OxCy) administered by inhalation of 21–100% oxygen for brief periods (15–90 min), daily for 5 days, using a rat model of acute MI. Myocardial oxygen tension (pO(2)), cardiac function and pro-survival/apoptotic signaling molecules were used as markers of treatment outcome. OxCy resulted in a significant reduction of infarct size and improvement of cardiac function. An optimal condition of 30-min OxCy with 95% oxygen + 5% CO(2) under normobaric conditions was found to be effective for cardioprotection.
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spelling pubmed-61209882018-09-12 Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction Prabhat, Anjali M. Kuppusamy, M. Lakshmi Naidu, Shan K. Meduru, Sarath Reddy, Praneeth T. Dominic, Abishai Khan, Mahmood Rivera, Brian K. Kuppusamy, Periannan Front Cardiovasc Med Cardiovascular Medicine Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of cardiac function, and congestive heart failure. While supplemental oxygen therapy has long been in practice to treat acute MI, there has not been a clear scientific basis for the observed beneficial effects. Further, there is no rationale for the amount or duration of administration of supplemental oxygenation for effective therapy. The goal of the present study was to determine an optimum oxygenation protocol that can be clinically applicable for treating acute MI. Using EPR oximetry, we studied the effect of exposure to supplemental oxygen cycling (OxCy) administered by inhalation of 21–100% oxygen for brief periods (15–90 min), daily for 5 days, using a rat model of acute MI. Myocardial oxygen tension (pO(2)), cardiac function and pro-survival/apoptotic signaling molecules were used as markers of treatment outcome. OxCy resulted in a significant reduction of infarct size and improvement of cardiac function. An optimal condition of 30-min OxCy with 95% oxygen + 5% CO(2) under normobaric conditions was found to be effective for cardioprotection. Frontiers Media S.A. 2018-08-28 /pmc/articles/PMC6120988/ /pubmed/30211171 http://dx.doi.org/10.3389/fcvm.2018.00114 Text en Copyright © 2018 Prabhat, Kuppusamy, Naidu, Meduru, Reddy, Dominic, Khan, Rivera and Kuppusamy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Prabhat, Anjali M.
Kuppusamy, M. Lakshmi
Naidu, Shan K.
Meduru, Sarath
Reddy, Praneeth T.
Dominic, Abishai
Khan, Mahmood
Rivera, Brian K.
Kuppusamy, Periannan
Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction
title Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction
title_full Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction
title_fullStr Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction
title_full_unstemmed Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction
title_short Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction
title_sort supplemental oxygen protects heart against acute myocardial infarction
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120988/
https://www.ncbi.nlm.nih.gov/pubmed/30211171
http://dx.doi.org/10.3389/fcvm.2018.00114
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