Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis

BACKGROUND & AIMS: Antibiotic (ABx) therapy is associated with increased risk for Crohn’s disease but underlying mechanisms are unknown. We observed high fecal serine protease activity (PA) to be a frequent side effect of ABx therapy. The aim of the present study was to unravel whether this rise...

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Detalles Bibliográficos
Autores principales: Yoon, Hongsup, Schaubeck, Monika, Lagkouvardos, Ilias, Blesl, Andreas, Heinzlmeir, Stephanie, Hahne, Hannes, Clavel, Thomas, Panda, Suchita, Ludwig, Christina, Kuster, Bernhard, Manichanh, Chaysavanh, Kump, Patrizia, Haller, Dirk, Hörmannsperger, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121113/
https://www.ncbi.nlm.nih.gov/pubmed/30182050
http://dx.doi.org/10.1016/j.jcmgh.2018.05.008

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