Cover Feature: Over 50 % (1)H and (13)C Polarization for Generating Hyperpolarized Metabolites—A para‐Hydrogen Approach (ChemistryOpen 9/2018)

The Cover Feature shows the nuclear magnetic resonance (NMR) signal enhancement of an acetate precursor for metabolic studies utilizing a new experiment. The observation of the normal/thermal NMR spectrum of (13)C nuclei in low concentrations is not possible and just noise is recorded (left). If unsaturated precursors of metabolites are reacted with para‐hydrogen in a magnetic field and newly designed pulsed NMR experiments entitled “efficient spin order transfer to heteronuclei via relayed INEPT chains (ESOTHERIC)” are subsequently applied, the signal is enhanced by 100 000 fold (right). The precursors are then reacted within seconds to yield the metabolite that can be utilized for metabolic studies. (Cover art by Harmut Sebesse) More information can be found in the Communication by S. Korchak et al. on page 672 in Issue 9, 2018 (DOI: https://doi.org/10.1002/open.201800086).[Image: see text]