Cargando…

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease

We have undertaken a systematic Mendelian randomization (MR) study using methylation quantitative trait loci (meQTL) as genetic instruments to assess the relationship between genetic variation, DNA methylation and 139 complex traits. Using two-sample MR, we identified 1148 associations across 61 tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richardson, Tom G, Haycock, Philip C, Zheng, Jie, Timpson, Nicholas J, Gaunt, Tom R, Davey Smith, George, Relton, Caroline L, Hemani, Gibran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121186/ https://www.ncbi.nlm.nih.gov/pubmed/29893838 http://dx.doi.org/10.1093/hmg/ddy210

Ejemplares similares

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk
por: Richardson, Tom G., et al.
Publicado: (2017)

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
por: Richardson, Tom G., et al.
Publicado: (2020)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
por: Cho, Yoonsu, et al.
Publicado: (2020)

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples
por: Fang, Si, et al.
Publicado: (2022)

A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits
por: Battram, Thomas, et al.
Publicado: (2022)

The use of negative control outcomes in Mendelian randomization to detect potential population stratification
por: Sanderson, Eleanor, et al.
Publicado: (2021)

Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization
por: Taylor, Kurt, et al.
Publicado: (2019)

Recent Developments in Mendelian Randomization Studies
por: Zheng, Jie, et al.
Publicado: (2017)

Mendelian randomization: genetic anchors for causal inference in epidemiological studies
por: Davey Smith, George, et al.
Publicado: (2014)

Evaluating the potential role of pleiotropy in Mendelian randomization studies
por: Hemani, Gibran, et al.
Publicado: (2018)

Leveraging brain cortex-derived molecular data to elucidate epigenetic and transcriptomic drivers of complex traits and disease
por: Hatcher, Charlie, et al.
Publicado: (2019)

Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes
por: Walker, Venexia M, et al.
Publicado: (2019)

The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study
por: Borges, Maria-Carolina, et al.
Publicado: (2022)

Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization—A Job for the Humble Heterogeneity Statistic?
por: Bowden, Jack, et al.
Publicado: (2018)

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics
por: Zheng, Jie, et al.
Publicado: (2018)

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
por: Richardson, Tom G, et al.
Publicado: (2019)

An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility
por: Richardson, Tom G, et al.
Publicado: (2019)

Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
por: Yu, Jian, et al.
Publicado: (2002)

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease
por: McGowan, Lucy M, et al.
Publicado: (2019)

Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
por: Hartwig, Fernando Pires, et al.
Publicado: (2016)

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants
por: Borges, Maria Carolina, et al.
Publicado: (2022)

Collapsed methylation quantitative trait loci analysis for low frequency and rare variants
por: Richardson, Tom G., et al.
Publicado: (2016)

Simultaneous Methylation-Level Assessment of Hundreds of CpG Sites by Targeted Bisulfite PCR Sequencing (TBPseq)
por: Jeon, Kyuheum, et al.
Publicado: (2017)

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases
por: Zhao, Huiling, et al.
Publicado: (2022)

Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study
por: Higbee, Daniel H., et al.
Publicado: (2021)

The MR-Base platform supports systematic causal inference across the human phenome
por: Hemani, Gibran, et al.
Publicado: (2018)

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies(1)
por: Haycock, Philip C, et al.
Publicado: (2016)

Design and quality control of large-scale two-sample Mendelian randomization studies
por: Haycock, Philip C, et al.
Publicado: (2023)

Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study
por: Richardson, Tom G, et al.
Publicado: (2022)

Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank
por: Carreras-Torres, Robert, et al.
Publicado: (2018)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways
por: Jamieson, Emily, et al.
Publicado: (2020)

Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study
por: Russell, Abigail Emma, et al.
Publicado: (2020)

Suppressive CpG
por: Van Epps, Heather L.
Publicado: (2005)

The role of common genetic variation in educational attainment and income: evidence from the National Child Development Study
por: Davies, Neil M., et al.
Publicado: (2015)

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
por: Zheng, Jie, et al.
Publicado: (2020)

Factors to preserve CpG-rich sequences in methylated CpG islands
por: Miyahara, Hiroki, et al.
Publicado: (2015)

The variant call format provides efficient and robust storage of GWAS summary statistics
por: Lyon, Matthew S., et al.
Publicado: (2021)

Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects
por: Zaghlool, Shaza B., et al.
Publicado: (2016)

Volumetric Analysis of Glioblastoma for Determining Which CpG Sites Should Be Tested by Pyrosequencing to Predict Temozolomide Efficacy
por: Hosoya, Tomohiro, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mg02rebnfvhfovfs5pfap3qcj4