ERK Signaling Controls Innate-like CD8(+) T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors

In mouse thymocyte development, signaling by the TCR through the ERK pathway is required for positive selection of conventional naive T cells. The Ets transcription factor ELK4 (SAP-1), an ERK-regulated cofactor of the SRF transcription factor, plays an important role in positive selection by activa...

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Detalles Bibliográficos
Autores principales: Maurice, Diane, Costello, Patrick, Sargent, Mathew, Treisman, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2018
Materias:
Immune System Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121213/
https://www.ncbi.nlm.nih.gov/pubmed/30068599
http://dx.doi.org/10.4049/jimmunol.1800704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121213/
https://www.ncbi.nlm.nih.gov/pubmed/30068599
http://dx.doi.org/10.4049/jimmunol.1800704

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