Cargando…
The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders
Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturbances may be associated with an altered gut microbiome in ASD. Furthermore, in ASD, these alterations are implicated in increased gut permeability, or “leaky gut”, which allows bact...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121241/ https://www.ncbi.nlm.nih.gov/pubmed/30071612 http://dx.doi.org/10.3390/ijms19082251 |
_version_ | 1783352421505826816 |
---|---|
author | Fowlie, Greta Cohen, Nicholas Ming, Xue |
author_facet | Fowlie, Greta Cohen, Nicholas Ming, Xue |
author_sort | Fowlie, Greta |
collection | PubMed |
description | Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturbances may be associated with an altered gut microbiome in ASD. Furthermore, in ASD, these alterations are implicated in increased gut permeability, or “leaky gut”, which allows bacterial metabolites to cross the gut barrier, impacting neurodevelopment during early childhood in susceptible subjects by way of gut-brain axis. In our review, we will discuss the interaction of gut microbiota and brain development in ASD and the signaling mechanisms underlying this interaction. We will also explore the potential for treatment of ASD by targeting the microbiome with probiotics. Finally, this paper will attempt to provide significance to the aggregation of the research in this area of research; providing our interpretations and assessments of future of this field. |
format | Online Article Text |
id | pubmed-6121241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61212412018-09-07 The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders Fowlie, Greta Cohen, Nicholas Ming, Xue Int J Mol Sci Commentary Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturbances may be associated with an altered gut microbiome in ASD. Furthermore, in ASD, these alterations are implicated in increased gut permeability, or “leaky gut”, which allows bacterial metabolites to cross the gut barrier, impacting neurodevelopment during early childhood in susceptible subjects by way of gut-brain axis. In our review, we will discuss the interaction of gut microbiota and brain development in ASD and the signaling mechanisms underlying this interaction. We will also explore the potential for treatment of ASD by targeting the microbiome with probiotics. Finally, this paper will attempt to provide significance to the aggregation of the research in this area of research; providing our interpretations and assessments of future of this field. MDPI 2018-08-01 /pmc/articles/PMC6121241/ /pubmed/30071612 http://dx.doi.org/10.3390/ijms19082251 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Fowlie, Greta Cohen, Nicholas Ming, Xue The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders |
title | The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders |
title_full | The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders |
title_fullStr | The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders |
title_full_unstemmed | The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders |
title_short | The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders |
title_sort | perturbance of microbiome and gut-brain axis in autism spectrum disorders |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121241/ https://www.ncbi.nlm.nih.gov/pubmed/30071612 http://dx.doi.org/10.3390/ijms19082251 |
work_keys_str_mv | AT fowliegreta theperturbanceofmicrobiomeandgutbrainaxisinautismspectrumdisorders AT cohennicholas theperturbanceofmicrobiomeandgutbrainaxisinautismspectrumdisorders AT mingxue theperturbanceofmicrobiomeandgutbrainaxisinautismspectrumdisorders AT fowliegreta perturbanceofmicrobiomeandgutbrainaxisinautismspectrumdisorders AT cohennicholas perturbanceofmicrobiomeandgutbrainaxisinautismspectrumdisorders AT mingxue perturbanceofmicrobiomeandgutbrainaxisinautismspectrumdisorders |