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The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders

Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturbances may be associated with an altered gut microbiome in ASD. Furthermore, in ASD, these alterations are implicated in increased gut permeability, or “leaky gut”, which allows bact...

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Detalles Bibliográficos
Autores principales: Fowlie, Greta, Cohen, Nicholas, Ming, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121241/
https://www.ncbi.nlm.nih.gov/pubmed/30071612
http://dx.doi.org/10.3390/ijms19082251
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author Fowlie, Greta
Cohen, Nicholas
Ming, Xue
author_facet Fowlie, Greta
Cohen, Nicholas
Ming, Xue
author_sort Fowlie, Greta
collection PubMed
description Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturbances may be associated with an altered gut microbiome in ASD. Furthermore, in ASD, these alterations are implicated in increased gut permeability, or “leaky gut”, which allows bacterial metabolites to cross the gut barrier, impacting neurodevelopment during early childhood in susceptible subjects by way of gut-brain axis. In our review, we will discuss the interaction of gut microbiota and brain development in ASD and the signaling mechanisms underlying this interaction. We will also explore the potential for treatment of ASD by targeting the microbiome with probiotics. Finally, this paper will attempt to provide significance to the aggregation of the research in this area of research; providing our interpretations and assessments of future of this field.
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spelling pubmed-61212412018-09-07 The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders Fowlie, Greta Cohen, Nicholas Ming, Xue Int J Mol Sci Commentary Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturbances may be associated with an altered gut microbiome in ASD. Furthermore, in ASD, these alterations are implicated in increased gut permeability, or “leaky gut”, which allows bacterial metabolites to cross the gut barrier, impacting neurodevelopment during early childhood in susceptible subjects by way of gut-brain axis. In our review, we will discuss the interaction of gut microbiota and brain development in ASD and the signaling mechanisms underlying this interaction. We will also explore the potential for treatment of ASD by targeting the microbiome with probiotics. Finally, this paper will attempt to provide significance to the aggregation of the research in this area of research; providing our interpretations and assessments of future of this field. MDPI 2018-08-01 /pmc/articles/PMC6121241/ /pubmed/30071612 http://dx.doi.org/10.3390/ijms19082251 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Fowlie, Greta
Cohen, Nicholas
Ming, Xue
The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders
title The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders
title_full The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders
title_fullStr The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders
title_full_unstemmed The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders
title_short The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders
title_sort perturbance of microbiome and gut-brain axis in autism spectrum disorders
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121241/
https://www.ncbi.nlm.nih.gov/pubmed/30071612
http://dx.doi.org/10.3390/ijms19082251
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