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Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults

The purpose of this study is to understand among a convenience sample of 400 adults aged 60 years of age or older (1) reasons for being willing or unwilling to participate in a vaccine clinical research study and (2) overall perceptions about vaccine clinical research. A cross-sectional study using...

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Autores principales: Raheja, Divyanshu, Davila, Evelyn P., Johnson, Eric T., Deović, Rijalda, Paine, Michele, Rouphael, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121248/
https://www.ncbi.nlm.nih.gov/pubmed/30110896
http://dx.doi.org/10.3390/ijerph15081743
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author Raheja, Divyanshu
Davila, Evelyn P.
Johnson, Eric T.
Deović, Rijalda
Paine, Michele
Rouphael, Nadine
author_facet Raheja, Divyanshu
Davila, Evelyn P.
Johnson, Eric T.
Deović, Rijalda
Paine, Michele
Rouphael, Nadine
author_sort Raheja, Divyanshu
collection PubMed
description The purpose of this study is to understand among a convenience sample of 400 adults aged 60 years of age or older (1) reasons for being willing or unwilling to participate in a vaccine clinical research study and (2) overall perceptions about vaccine clinical research. A cross-sectional study using a sample of older adults residing in the metro-Atlanta area and surrounding neighborhoods was conducted. The study questionnaire contained 37 questions, including questions about socio-demographics and perceptions about clinical trial processes. Statistical analysis was conducted using logistic regression. The adjusted modeling results indicated that sex, distance to research clinic, and being informed about the research findings played a role in the likelihood of an elderly person participating in a vaccine study. Males were more likely to participate in clinical trials as compared to females (OR: 2.486; CI: 1.042–5.934). Most participants were willing to travel up to 25 miles from the research clinic. Of the respondents, 45% were unlikely to participate if the results of the current trial are not shared. Improving access to clinical trials in terms of distance traveled and ensuring streamlined processes to inform participants about the results of the trial in the future would increase willingness to participate in vaccine clinical trials. The survey could serve as a useful tool for conducting vaccine studies and other clinical trials by understanding the barriers specific to the elderly.
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spelling pubmed-61212482018-09-07 Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults Raheja, Divyanshu Davila, Evelyn P. Johnson, Eric T. Deović, Rijalda Paine, Michele Rouphael, Nadine Int J Environ Res Public Health Article The purpose of this study is to understand among a convenience sample of 400 adults aged 60 years of age or older (1) reasons for being willing or unwilling to participate in a vaccine clinical research study and (2) overall perceptions about vaccine clinical research. A cross-sectional study using a sample of older adults residing in the metro-Atlanta area and surrounding neighborhoods was conducted. The study questionnaire contained 37 questions, including questions about socio-demographics and perceptions about clinical trial processes. Statistical analysis was conducted using logistic regression. The adjusted modeling results indicated that sex, distance to research clinic, and being informed about the research findings played a role in the likelihood of an elderly person participating in a vaccine study. Males were more likely to participate in clinical trials as compared to females (OR: 2.486; CI: 1.042–5.934). Most participants were willing to travel up to 25 miles from the research clinic. Of the respondents, 45% were unlikely to participate if the results of the current trial are not shared. Improving access to clinical trials in terms of distance traveled and ensuring streamlined processes to inform participants about the results of the trial in the future would increase willingness to participate in vaccine clinical trials. The survey could serve as a useful tool for conducting vaccine studies and other clinical trials by understanding the barriers specific to the elderly. MDPI 2018-08-14 2018-08 /pmc/articles/PMC6121248/ /pubmed/30110896 http://dx.doi.org/10.3390/ijerph15081743 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Raheja, Divyanshu
Davila, Evelyn P.
Johnson, Eric T.
Deović, Rijalda
Paine, Michele
Rouphael, Nadine
Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults
title Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults
title_full Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults
title_fullStr Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults
title_full_unstemmed Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults
title_short Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults
title_sort willingness to participate in vaccine-related clinical trials among older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121248/
https://www.ncbi.nlm.nih.gov/pubmed/30110896
http://dx.doi.org/10.3390/ijerph15081743
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