Intracellular Ca(2+) Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration

Under pro-inflammatory conditions, astrocytes become reactive and acquire a migratory phenotype. Our results show that hemichannels formed by connexin 43 (Cx43) play an important role in Thy-1-induced astrocyte migration. The neuronal protein Thy-1 binds to αvβ3 integrin in astrocytes, thereby leadi...

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Detalles Bibliográficos
Autores principales: Lagos-Cabré, Raúl, Brenet, Marianne, Díaz, Jorge, Pérez, Ramón D., Pérez, Leonardo A., Herrera-Molina, Rodrigo, Quest, Andrew F. G., Leyton, Lisette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121259/
https://www.ncbi.nlm.nih.gov/pubmed/30049932
http://dx.doi.org/10.3390/ijms19082179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121259/
https://www.ncbi.nlm.nih.gov/pubmed/30049932
http://dx.doi.org/10.3390/ijms19082179

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