Cargando…

Intracellular Ca(2+) Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration

Under pro-inflammatory conditions, astrocytes become reactive and acquire a migratory phenotype. Our results show that hemichannels formed by connexin 43 (Cx43) play an important role in Thy-1-induced astrocyte migration. The neuronal protein Thy-1 binds to αvβ3 integrin in astrocytes, thereby leadi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lagos-Cabré, Raúl, Brenet, Marianne, Díaz, Jorge, Pérez, Ramón D., Pérez, Leonardo A., Herrera-Molina, Rodrigo, Quest, Andrew F. G., Leyton, Lisette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121259/ https://www.ncbi.nlm.nih.gov/pubmed/30049932 http://dx.doi.org/10.3390/ijms19082179

Ejemplares similares

Connexins in Astrocyte Migration
por: Lagos-Cabré, Raúl, et al.
Publicado: (2020)

Connexin 43 hemichannels and intracellular signaling in bone cells
por: Plotkin, Lilian I.
Publicado: (2014)

Connexin43 Hemichannel-Mediated Regulation of Connexin43
por: Li, Kai, et al.
Publicado: (2013)

Connexin Hemichannels in Astrocytes: Role in CNS Disorders
por: Xing, LingYan, et al.
Publicado: (2019)

The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions
por: Liang, Zhen, et al.
Publicado: (2020)

Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation
por: Hua, Rui, et al.
Publicado: (2022)

Protein kinase B (AKT) upregulation and Thy-1-α(v)β(3) integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis
por: Pérez-Núñez, Ramón, et al.
Publicado: (2023)

Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status
por: Chi, Yuan, et al.
Publicado: (2016)

Blockade of Glial Connexin 43 Hemichannels Reduces Food Intake
por: Guillebaud, Florent, et al.
Publicado: (2020)

Data on Connexin 43 hemichannels regulation of cellular redox in lens
por: Quan, Yumeng, et al.
Publicado: (2021)

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes
por: Abudara, Verónica, et al.
Publicado: (2014)

Thy-1 (CD90)-Induced Metastatic Cancer Cell Migration and Invasion Are β3 Integrin-Dependent and Involve a Ca(2+)/P2X7 Receptor Signaling Axis
por: Brenet, Marianne, et al.
Publicado: (2021)

Involvement of connexin43 hemichannel in ATP release after γ-irradiation
por: Ohshima, Yasuhiro, et al.
Publicado: (2012)

Circadian coordination of ATP release in the urothelium via connexin43 hemichannels
por: Sengiku, Atsushi, et al.
Publicado: (2018)

Connexin 43 hemichannels protect bone loss during estrogen deficiency
por: Ma, Liang, et al.
Publicado: (2019)

Connexin 43 Mutations Lead to Increased Hemichannel Functionality in Skin Disease
por: Cocozzelli, Anthony G., et al.
Publicado: (2019)

Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias
por: Lillo, Mauricio A., et al.
Publicado: (2023)

The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring
por: Chávez, Carolina E., et al.
Publicado: (2019)

Diverse inflammatory threats modulate astrocytes Ca(2+) signaling via connexin43 hemichannels in organotypic spinal slices
por: Panattoni, Giulia, et al.
Publicado: (2021)

Connexin hemichannels in the lens
por: Beyer, Eric C., et al.
Publicado: (2014)

Functional analysis of hemichannels and gap-junctional channels formed by connexins 43 and 46
por: Hoang, Quan V., et al.
Publicado: (2010)

Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases
por: Li, Wei, et al.
Publicado: (2018)

Connexin43 mutations linked to skin disease have augmented hemichannel activity
por: Srinivas, Miduturu, et al.
Publicado: (2019)

Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels
por: Khalil, Antoine A., et al.
Publicado: (2020)

Cardiac Connexin-43 Hemichannels and Pannexin1 Channels: Provocative Antiarrhythmic Targets
por: Andelova, Katarina, et al.
Publicado: (2020)

Effects of Drugs Formerly Proposed for COVID-19 Treatment on Connexin43 Hemichannels
por: Cooreman, Axelle, et al.
Publicado: (2022)

HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function
por: Gajardo-Gómez, Rosario, et al.
Publicado: (2020)

Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?
por: Retamal, Mauricio A., et al.
Publicado: (2017)

Astrocytic α(V)β(3) Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1
por: Herrera-Molina, Rodrigo, et al.
Publicado: (2012)

Connexin26 mutations causing palmoplantar keratoderma and deafness interact with connexin43, modifying gap junction and hemichannel properties
por: Shuja, Zunaira, et al.
Publicado: (2016)

Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity
por: Maatouk, Layal, et al.
Publicado: (2018)

Regulation of Connexin Hemichannels by Monovalent Cations
por: Srinivas, Miduturu, et al.
Publicado: (2006)

The Role of Connexin Hemichannels in Inflammatory Diseases
por: Peng, Bo, et al.
Publicado: (2022)

Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy
por: Guo, Anni, et al.
Publicado: (2022)

Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
por: Mostafavi, Hossein, et al.
Publicado: (2014)

Connexin 43 Controls the Astrocyte Immunoregulatory Phenotype
por: Boulay, Anne-Cécile, et al.
Publicado: (2018)

Connexin 43 Hemichannels Regulate the Expression of Wound Healing-Associated Genes in Human Gingival Fibroblasts
por: Tarzemany, Rana, et al.
Publicado: (2017)

Connexin 43 and Its Hemichannels Mediate Hypoxia–Ischemia-Induced Cell Death in Neonatal Rats
por: Wang, Jingwei, et al.
Publicado: (2014)

Xentry-Gap19 inhibits Connexin43 hemichannel opening especially during hypoxic injury
por: Coutinho, Frazer P., et al.
Publicado: (2020)

α(V)β(3) Integrin regulates astrocyte reactivity
por: Lagos-Cabré, Raúl, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7h5ei02rc7sguqt6n7s4ig3633