Cargando…

Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks

Molecular classification has improved the knowledge of medulloblastoma (MB), the most common malignant brain tumour in children, however current treatments cause severe side effects in patients. Cancer stem cells (CSCs) have been described in MB and represent a sub population characterised by self-r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Po, Agnese, Abballe, Luana, Sabato, Claudia, Gianno, Francesca, Chiacchiarini, Martina, Catanzaro, Giuseppina, De Smaele, Enrico, Giangaspero, Felice, Ferretti, Elisabetta, Miele, Evelina, Besharat, Zein Mersini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121264/ https://www.ncbi.nlm.nih.gov/pubmed/30096798 http://dx.doi.org/10.3390/ijms19082326

Ejemplares similares

Low Expression of miR-466f-3p Sustains Epithelial to Mesenchymal Transition in Sonic Hedgehog Medulloblastoma Stem Cells Through Vegfa-Nrp2 Signaling Pathway
por: Besharat, Zein Mersini, et al.
Publicado: (2018)

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells
por: Abballe, Luana, et al.
Publicado: (2018)

BRAF mutant colorectal cancer: ErbB2 expression levels as predictive factor for the response to combined BRAF/ErbB inhibitors
por: Miele, Evelina, et al.
Publicado: (2020)

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells
por: Miele, Evelina, et al.
Publicado: (2017)

Downregulation of miR‐326 and its host gene β‐arrestin1 induces pro‐survival activity of E2F1 and promotes medulloblastoma growth
por: Miele, Evelina, et al.
Publicado: (2020)

Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells
por: Po, Agnese, et al.
Publicado: (2020)

Circulating MicroRNAs in Elderly Type 2 Diabetic Patients
por: Catanzaro, Giuseppina, et al.
Publicado: (2018)

β-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest
por: Po, Agnese, et al.
Publicado: (2017)

Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs)
por: Catanzaro, Giuseppina, et al.
Publicado: (2017)

MEDB-09. Unraveling the role of unfolded protein response in medulloblastoma cancer stem cells
por: Spinello, Zaira, et al.
Publicado: (2022)

The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
por: Miele, Evelina, et al.
Publicado: (2017)

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs
por: Catanzaro, Giuseppina, et al.
Publicado: (2016)

MiR-1248: a new prognostic biomarker able to identify supratentorial hemispheric pediatric low-grade gliomas patients associated with progression
por: Catanzaro, Giuseppina, et al.
Publicado: (2022)

Application of Small Epigenetic Modulators in Pediatric Medulloblastoma
por: Zwergel, Clemens, et al.
Publicado: (2018)

Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy
por: Citarella, Anna, et al.
Publicado: (2023)

Foxm1 controls a pro-stemness microRNA network in neural stem cells
por: Besharat, Zein Mersini, et al.
Publicado: (2018)

Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
por: Carta, Roberto, et al.
Publicado: (2020)

MEDB-46. ONC201 affects Group 3 Medulloblastoma growth by impairing cancer stem cells
por: Abballe, Luana, et al.
Publicado: (2022)

Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma
por: Jenkins, Noah C, et al.
Publicado: (2014)

HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma
por: Bell, Jonathan B., et al.
Publicado: (2018)

Nanoparticles for Drug and Gene Delivery in Pediatric Brain Tumors’ Cancer Stem Cells: Current Knowledge and Future Perspectives
por: Abballe, Luana, et al.
Publicado: (2023)

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2
por: Spiombi, Eleonora, et al.
Publicado: (2019)

Modeling medulloblastoma in vivo and with human cerebellar organoids
por: Ballabio, Claudio, et al.
Publicado: (2020)

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma
por: Brun, Sonja N., et al.
Publicado: (2014)

MBCL-21. GERMLINE ELONGATOR MUTATIONS IN SONIC HEDGEHOG MEDULLOBLASTOMA
por: Robinson, Giles W, et al.
Publicado: (2020)

Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo
por: MacDonald, Tobey J., et al.
Publicado: (2021)

Clinical and molecular analysis of smoothened inhibitors in Sonic Hedgehog medulloblastoma
por: Pereira, Victor, et al.
Publicado: (2021)

Generating a mouse model for relapsed Sonic Hedgehog medulloblastoma
por: Heller, Allie, et al.
Publicado: (2023)

Sonic hedgehog signaling: Alternative splicing and pathogenic role in medulloblastoma
por: Qu, Meiyu, et al.
Publicado: (2022)

A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma
por: White, Christine L., et al.
Publicado: (2019)

TMOD-05. GENOME-WIDE DNA METHYLATION PROFILE: A POWERFUL STRATEGY TO RECAPITULATE HETEROGENEITY OF PEDIATRIC BRAIN TUMORS IN PRIMARY CELL LINES
por: Pedace, Lucia, et al.
Publicado: (2021)

Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
por: Maximov, Victor, et al.
Publicado: (2019)

Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma
por: Robinson, M. Hope, et al.
Publicado: (2019)

MEDB-57.GNAS inactivation as a driver for sonic hedgehog-activated medulloblastoma
por: Goode, Erin, et al.
Publicado: (2022)

Effects of metformin on Sonic hedgehog subgroup medulloblastoma progression: In vitro and in vivo studies
por: Fang, Huangyi, et al.
Publicado: (2022)

KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasis
por: Sanghrajka, Reeti Mayur, et al.
Publicado: (2023)

MODL-23. DNA METHYLATION AND COPY NUMBER VARIATION PROFILE FOR CHARACTERIZATION OF PEDIATRIC BRAIN TUMOR PRIMARY CELL LINES
por: Pedace, Lucia, et al.
Publicado: (2020)

WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma
por: Wen, Jing, et al.
Publicado: (2016)

G-Protein Gα(s) controls medulloblastoma initiation by suppressing sonic hedgehog signaling
por: He, Xuelian, et al.
Publicado: (2014)

Dural-based atypical teratoid/rhabdoid tumor in an adult: DNA methylation profiling as a tool for the diagnosis
por: Hiba, Alzoubi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_uijpsldt0kq5ltuk4mgstrerb7