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Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs

Cisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-b...

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Detalles Bibliográficos
Autores principales: Lambert, Ian Henry, Sørensen, Belinda Halling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121265/
https://www.ncbi.nlm.nih.gov/pubmed/30071606
http://dx.doi.org/10.3390/ijms19082249
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author Lambert, Ian Henry
Sørensen, Belinda Halling
author_facet Lambert, Ian Henry
Sørensen, Belinda Halling
author_sort Lambert, Ian Henry
collection PubMed
description Cisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-based drugs are accumulated via membrane-bound transporters, translocated to the nucleus, where they trigger various intracellular cell death programs through DNA interaction. Here we illustrate how resistance to Pt-based drugs, acquired through limitation in the activity/subcellular localization of canonical drug transporters, might be circumvented by the facilitated uptake of Pt-based drug complexes via nanocarriers/endocytosis or lipophilic drugs by diffusion.
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spelling pubmed-61212652018-09-07 Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs Lambert, Ian Henry Sørensen, Belinda Halling Int J Mol Sci Review Cisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-based drugs are accumulated via membrane-bound transporters, translocated to the nucleus, where they trigger various intracellular cell death programs through DNA interaction. Here we illustrate how resistance to Pt-based drugs, acquired through limitation in the activity/subcellular localization of canonical drug transporters, might be circumvented by the facilitated uptake of Pt-based drug complexes via nanocarriers/endocytosis or lipophilic drugs by diffusion. MDPI 2018-08-01 /pmc/articles/PMC6121265/ /pubmed/30071606 http://dx.doi.org/10.3390/ijms19082249 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lambert, Ian Henry
Sørensen, Belinda Halling
Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs
title Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs
title_full Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs
title_fullStr Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs
title_full_unstemmed Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs
title_short Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs
title_sort facilitating the cellular accumulation of pt-based chemotherapeutic drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121265/
https://www.ncbi.nlm.nih.gov/pubmed/30071606
http://dx.doi.org/10.3390/ijms19082249
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