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Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs
Cisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-b...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121265/ https://www.ncbi.nlm.nih.gov/pubmed/30071606 http://dx.doi.org/10.3390/ijms19082249 |
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author | Lambert, Ian Henry Sørensen, Belinda Halling |
author_facet | Lambert, Ian Henry Sørensen, Belinda Halling |
author_sort | Lambert, Ian Henry |
collection | PubMed |
description | Cisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-based drugs are accumulated via membrane-bound transporters, translocated to the nucleus, where they trigger various intracellular cell death programs through DNA interaction. Here we illustrate how resistance to Pt-based drugs, acquired through limitation in the activity/subcellular localization of canonical drug transporters, might be circumvented by the facilitated uptake of Pt-based drug complexes via nanocarriers/endocytosis or lipophilic drugs by diffusion. |
format | Online Article Text |
id | pubmed-6121265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61212652018-09-07 Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs Lambert, Ian Henry Sørensen, Belinda Halling Int J Mol Sci Review Cisplatin, carboplatin, and oxaliplatin are Pt-based drugs used in the chemotherapeutic eradication of cancer cells. Although most cancer patient cells initially respond well to the treatment, the clinical effectiveness declines over time as the cancer cells develop resistance to the drugs. The Pt-based drugs are accumulated via membrane-bound transporters, translocated to the nucleus, where they trigger various intracellular cell death programs through DNA interaction. Here we illustrate how resistance to Pt-based drugs, acquired through limitation in the activity/subcellular localization of canonical drug transporters, might be circumvented by the facilitated uptake of Pt-based drug complexes via nanocarriers/endocytosis or lipophilic drugs by diffusion. MDPI 2018-08-01 /pmc/articles/PMC6121265/ /pubmed/30071606 http://dx.doi.org/10.3390/ijms19082249 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lambert, Ian Henry Sørensen, Belinda Halling Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title | Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_full | Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_fullStr | Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_full_unstemmed | Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_short | Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs |
title_sort | facilitating the cellular accumulation of pt-based chemotherapeutic drugs |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121265/ https://www.ncbi.nlm.nih.gov/pubmed/30071606 http://dx.doi.org/10.3390/ijms19082249 |
work_keys_str_mv | AT lambertianhenry facilitatingthecellularaccumulationofptbasedchemotherapeuticdrugs AT sørensenbelindahalling facilitatingthecellularaccumulationofptbasedchemotherapeuticdrugs |