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Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase
Although the signaling function of Na/K-ATPase has been studied for decades, the chasm between the pumping function and the signaling function of Na/K-ATPase is still an open issue. This article explores the relationship between ion pumping and signaling with attention to the amplification of oxidan...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121303/ https://www.ncbi.nlm.nih.gov/pubmed/30096926 http://dx.doi.org/10.3390/ijms19082347 |
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author | Wang, Weiguang Shapiro, Joseph I. |
author_facet | Wang, Weiguang Shapiro, Joseph I. |
author_sort | Wang, Weiguang |
collection | PubMed |
description | Although the signaling function of Na/K-ATPase has been studied for decades, the chasm between the pumping function and the signaling function of Na/K-ATPase is still an open issue. This article explores the relationship between ion pumping and signaling with attention to the amplification of oxidants through this signaling function. We specifically consider the Na/K-ATPase with respect to its signaling function as a superposition of different states described for its pumping function. We then examine how alterations in the relative amounts of these states could alter signaling through the Src-EGFR-ROS pathway. Using assumptions based on some experimental observations published by our laboratories and others, we develop some predictions regarding cellular oxidant stress. |
format | Online Article Text |
id | pubmed-6121303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61213032018-09-07 Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase Wang, Weiguang Shapiro, Joseph I. Int J Mol Sci Article Although the signaling function of Na/K-ATPase has been studied for decades, the chasm between the pumping function and the signaling function of Na/K-ATPase is still an open issue. This article explores the relationship between ion pumping and signaling with attention to the amplification of oxidants through this signaling function. We specifically consider the Na/K-ATPase with respect to its signaling function as a superposition of different states described for its pumping function. We then examine how alterations in the relative amounts of these states could alter signaling through the Src-EGFR-ROS pathway. Using assumptions based on some experimental observations published by our laboratories and others, we develop some predictions regarding cellular oxidant stress. MDPI 2018-08-09 /pmc/articles/PMC6121303/ /pubmed/30096926 http://dx.doi.org/10.3390/ijms19082347 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Weiguang Shapiro, Joseph I. Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase |
title | Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase |
title_full | Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase |
title_fullStr | Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase |
title_full_unstemmed | Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase |
title_short | Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase |
title_sort | quantum modeling: a bridge between the pumping and signaling functions of na/k-atpase |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121303/ https://www.ncbi.nlm.nih.gov/pubmed/30096926 http://dx.doi.org/10.3390/ijms19082347 |
work_keys_str_mv | AT wangweiguang quantummodelingabridgebetweenthepumpingandsignalingfunctionsofnakatpase AT shapirojosephi quantummodelingabridgebetweenthepumpingandsignalingfunctionsofnakatpase |